Protein Info for PGA1_c07920 in Phaeobacter inhibens DSM 17395

Annotation: signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 471 transmembrane" amino acids 16 to 37 (22 residues), see Phobius details amino acids 169 to 188 (20 residues), see Phobius details PF08521: 2CSK_N" amino acids 24 to 164 (141 residues), 118.4 bits, see alignment E=3.9e-38 PF00512: HisKA" amino acids 243 to 299 (57 residues), 30.5 bits, see alignment 4.5e-11 PF02518: HATPase_c" amino acids 351 to 470 (120 residues), 77.4 bits, see alignment E=1.7e-25

Best Hits

KEGG orthology group: K07649, two-component system, OmpR family, sensor histidine kinase TctE [EC: 2.7.13.3] (inferred from 67% identity to sil:SPO0188)

Predicted SEED Role

"Tricarboxylate transport sensor protein TctE"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EXC3 at UniProt or InterPro

Protein Sequence (471 amino acids)

>PGA1_c07920 signal transduction histidine kinase (Phaeobacter inhibens DSM 17395)
MSRALPTSGSIRRRLTLQLVGSAAFLASLLFFIVLVFTRDVSQRTHDSILQASATSIMDS
VSVRSGDVTVDIPYSALSMLGNVSDDRVFYRVAQNDRLLTGYGDLPLPDLLPQRGQPRFD
TAPYKGDSIRMVTLARRVSLNGQVSDVVISVAQTREGQSAQLAELTRTALQLGLGFFMIA
AFLAIWAAQSSIRPLAELAEAVSRRGPKDLRPVRRPVPSEMIPLVTSLNRFIERLRVSLS
RSEDFIAEAAHRVRTPLATVRAQAEITLRRVERDENRASLREMIRAIDESSRAAGQLLDH
AMVTFRTDSLLREEVDLGALSRELLNRLRPIAELKDIALHSDLPQTPALSGDPILIQNAV
RNLLDNAIKYAPSESDIQVILRKEGAELRLSIIDEAGGFPSGDTEALTARFARGANAEGT
IGSGLGLTIAREVVEAHGGRLTIAPSQATSGPPAASPRREGSCVSLCFPVL