Protein Info for HP15_755 in Marinobacter adhaerens HP15

Annotation: Mg2+ and Co2+ transporter CorB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 62 to 86 (25 residues), see Phobius details amino acids 92 to 111 (20 residues), see Phobius details amino acids 129 to 156 (28 residues), see Phobius details PF01595: CNNM" amino acids 11 to 181 (171 residues), 184.5 bits, see alignment E=2.4e-58 PF00571: CBS" amino acids 204 to 257 (54 residues), 17 bits, see alignment 9e-07 amino acids 277 to 325 (49 residues), 24.7 bits, see alignment 3.6e-09 PF03471: CorC_HlyC" amino acids 342 to 416 (75 residues), 57 bits, see alignment E=2.4e-19

Best Hits

Swiss-Prot: 47% identical to YFJD_ECOLI: UPF0053 inner membrane protein YfjD (yfjD) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 90% identity to maq:Maqu_2313)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PQH6 at UniProt or InterPro

Protein Sequence (428 amino acids)

>HP15_755 Mg2+ and Co2+ transporter CorB (Marinobacter adhaerens HP15)
MNETSLTALFILLVGLILLSGFFSSSETGMMSLNRYRLKHMAKTGHKGAKRAQGLLQRTD
QLIGVILIGNNFVNIFASSIATVIAIRVWGDAGIAIATILLTIVILIFAEVTPKTLAALF
PEKIAFPASYILGPLLKILYPIVWAVNLFTGGILKLLGVSAADAANDHLSREELRTLVNE
AGALIPAKHKDMLVSILDLEKVTVNDIMVPRNEVVGIDLEDDTDTILRQLRSSQHTRLPV
FKGDINNIQGILHLRSASKLLQQEEINKAMIMQLCQEPYFIPESTPLNTQLINFQKGRRR
FGVVVDEYGDVLGLATLEDILEEIVGDFTTDYAATSPDIIPQDNGTFIIDGTSAVRTINK
TLGWKLPTDGPKTLNGLITETLENIPDTNVCLKVDGHRVEVLQIKDNVVKAAIVHPKKRK
KRSLSLKQ