Protein Info for Psest_0785 in Pseudomonas stutzeri RCH2

Annotation: Thioredoxin reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 PF00890: FAD_binding_2" amino acids 14 to 46 (33 residues), 22.9 bits, see alignment 1.4e-08 PF07992: Pyr_redox_2" amino acids 14 to 291 (278 residues), 86.2 bits, see alignment E=8.4e-28 PF13450: NAD_binding_8" amino acids 17 to 46 (30 residues), 24.9 bits, see alignment (E = 6.2e-09)

Best Hits

Predicted SEED Role

"Thioredoxin reductase (EC 1.8.1.9)" in subsystem Glycine reductase, sarcosine reductase and betaine reductase or Thioredoxin-disulfide reductase or Wyeosine-MimG Biosynthesis (EC 1.8.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.9

Use Curated BLAST to search for 1.8.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GF53 at UniProt or InterPro

Protein Sequence (315 amino acids)

>Psest_0785 Thioredoxin reductase (Pseudomonas stutzeri RCH2)
MTTDQANPSTTVTDCLIVGGGPAGLTAALYLARFRRSCLVVDAGSSRASWIPRSRNYPGF
PPGINGNDLLARLREQASGYGARLEHGRVEHIEPHTEGFSVRYGENVCVTRRIILATGIE
DSLPDMPDIETAIAEGKVRLCAICDGYEVDGDNVAVYGEAENAISHAVFLRTFTDRVTVV
VHGEQDACDQAIALAEHYAIRVISDRVESLHPCETGIELLTWRGERHHFDIIYPSLGARF
RSELAVQLGLDCDECGGVNVDEHRQTSLRGLYAIGDVTMGLKQISVAIGQAAQAATAVHN
SLEANPWGGSTVAGR