Protein Info for HP15_747 in Marinobacter adhaerens HP15

Annotation: integral membrane sensor signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 491 transmembrane" amino acids 184 to 208 (25 residues), see Phobius details PF00512: HisKA" amino acids 263 to 327 (65 residues), 49.5 bits, see alignment E=5.2e-17 PF02518: HATPase_c" amino acids 376 to 484 (109 residues), 86.9 bits, see alignment E=1.9e-28 PF13589: HATPase_c_3" amino acids 380 to 450 (71 residues), 26.2 bits, see alignment E=1.1e-09

Best Hits

KEGG orthology group: K07639, two-component system, OmpR family, sensor histidine kinase RstB [EC: 2.7.13.3] (inferred from 68% identity to maq:Maqu_2320)

Predicted SEED Role

"Sensory histidine kinase in two-component regulatory system with RstA" in subsystem Orphan regulatory proteins

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PQG8 at UniProt or InterPro

Protein Sequence (491 amino acids)

>HP15_747 integral membrane sensor signal transduction histidine kinase (Marinobacter adhaerens HP15)
MRSQFWHERFPEPLMRWLAAAPAPLQQYHWLSSTVDLRMGAASRFNLSPVALERLGYGQV
VGIDSDVGYRVLVTGLSGEILQLRLNEPYRDVSETIGLIFRWHLDSASADDRLNVASQMA
RSLNVQVQTLDDADLLPDSDVLDQVAERGLAFYTDESDGCGRVIVQLSDGELYRIDMPAG
FDPWAWPVVLLLVLVLGGVLAVAVFLALREVDSNLRTVESVAVRIARGEMSARVQAGEGT
LVTRLASSFNGMAEHIQRLVQVQREMIHAVSHELRTPVARIRFGVQMIEDCQDEAALQRQ
LDGIDGDIQELDELIDEILTYARLEQGGPVFSLQETSITDIVRQVVSEQQMVRPELSIEG
NIDEVSERWALSDIEPRYLHRAIQNLVGNAGRYAAGKVLVSCHFDEDNCRVDVEDDGPGI
PEEDWEKVFTAFARLDDSRTRTSGGYGLGLSIVRRILYWHGGHAFVSRSDTLGGAKFSLV
WPRKKPVDSIV