Protein Info for PGA1_c07330 in Phaeobacter inhibens DSM 17395

Annotation: beta-galactosidase 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 639 PF02449: Glyco_hydro_42" amino acids 8 to 393 (386 residues), 484 bits, see alignment E=4.1e-149 PF08532: Glyco_hydro_42M" amino acids 402 to 591 (190 residues), 83.3 bits, see alignment E=1.8e-27

Best Hits

Swiss-Prot: 58% identical to BGAL_THETH: Beta-galactosidase from Thermus thermophilus

KEGG orthology group: K12308, beta-galactosidase [EC: 3.2.1.23] (inferred from 76% identity to sit:TM1040_3492)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DMW1 at UniProt or InterPro

Protein Sequence (639 amino acids)

>PGA1_c07330 beta-galactosidase 1 (Phaeobacter inhibens DSM 17395)
MQRTLGTCYYPEHWPEDIWQEDAARMVAAGLTWVRIGEFSWSRIEPNPGDLQWDWLDRAI
DTLVAAGLKVVLGTPTATPPRWMVDRHPDMFALDADGRSRGFGSRRHYCFSHTGYRAEAR
RIVTLMAERYGPGDRIAAWQTDNEYGCHDTTISYSPAAAAAFTHWLEVRFNGDICALNAA
WGNVFWSMEYERFDQIGLPNLTVTEPNPAHVQAFRRFSSDQVVSFNRDQVEILRAHSDAP
IAHNYMGRVTDFDHYKVGEDLEIASWDSYPLGFLEDRVGASAEDQRRYARQGDPDFQAFH
HDLYRAVGRGRWWVMEQQPGPVNWAPYNPAPLPGMVRFWTWEAFAHGAEAVCYFRWRQAP
FAQEQLHAGLLRPDSAETPAMIEARQVAEELTSADEVAPSQAPVALLFDYDAEWAWQVQP
HGKGLSYFDLVLDHYRALRRAGLSIDIVPPTQTDFTGYELILAPGLVHLPDDLRGALADA
TGLRLYGPRTAARDEDFRIPTSPLPPALQGLDIVVAAVESLRPDMPLPLANGDGAVVGYL
ETLDGEGSVLIETSAGHAVAVAADNQVYCAGWLDPLGLDHLIATLCARAGVNIRKMPEGV
RMRQTATEEFWFNHLAEPVETEVGTLPPAGILRRAREEA