Protein Info for HP15_605 in Marinobacter adhaerens HP15

Annotation: peptidoglycan glycosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 629 transmembrane" amino acids 21 to 39 (19 residues), see Phobius details TIGR03423: penicillin-binding protein 2" amino acids 18 to 610 (593 residues), 773.9 bits, see alignment E=5.7e-237 PF03717: PBP_dimer" amino acids 63 to 234 (172 residues), 160.8 bits, see alignment E=4.9e-51 PF00905: Transpeptidase" amino acids 267 to 606 (340 residues), 219.3 bits, see alignment E=7.2e-69

Best Hits

KEGG orthology group: K05515, penicillin-binding protein 2 (inferred from 82% identity to maq:Maqu_2413)

Predicted SEED Role

"Penicillin-binding protein 2 (PBP-2)" in subsystem Peptidoglycan Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PP57 at UniProt or InterPro

Protein Sequence (629 amino acids)

>HP15_605 peptidoglycan glycosyltransferase (Marinobacter adhaerens HP15)
MPWGEFKDTAAERRLFQRRSLVMLVLVMLAIGGLIARMYQLQVVEHEIYTTLSDKNRVQV
QSVPPPRGLVYDRNNTLLAENRPVFSVTLVPERVQGMDDTLAQLDAILEISEEDRERFQR
RLQEPRRPFQEIPLRYDLNEQEMARLAVHRHELPGVEVKAELVRYYPHSELTAHALGFVG
RINRDELQRIDPVNYAGTNYIGKSGIERFYEEILHGQVGYQHVETNARGRTLRVLERENP
VPGEDLQLHLDLRLQQRAHELLDGRRGAIIAIEPDTGGILALASVPGFDANKFVTGISVN
DYRELSDSKDKPLFNRALRGQYPPGSTLKPMLAVAALDSGATTRDYTIWDPGHFRLNQGG
RVWRDWKRTGHGWVDLKDAVAESCDVYFYEAAVEMGVDTMHSYLSHFGFGEDATLDVSGA
LSGLLPSRDWKRAVRNEPWYPGDSVNLGIGQGFMLATPLQLATATALIANRGEWVEPRLL
KDIKGDRPVEEFLPAETHEPLKLKNPDDWEYVVETMVEVMHGAKGTARGAGRGAPYKMAG
KTGTAQVFSLAEDEEYDEEEIRERLRDHALFVGFAPVDNPKIAVAVIVENGGSGSGTAAP
VARALFDSWLLDYGQGDSALVSGVGEVAD