Protein Info for Psest_0596 in Pseudomonas stutzeri RCH2

Annotation: heavy metal efflux pump (cobalt-zinc-cadmium)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1054 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 339 to 357 (19 residues), see Phobius details amino acids 363 to 381 (19 residues), see Phobius details amino acids 389 to 410 (22 residues), see Phobius details amino acids 442 to 464 (23 residues), see Phobius details amino acids 483 to 504 (22 residues), see Phobius details amino acids 534 to 553 (20 residues), see Phobius details amino acids 873 to 890 (18 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 923 to 947 (25 residues), see Phobius details amino acids 980 to 998 (19 residues), see Phobius details amino acids 1008 to 1033 (26 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1045 (1045 residues), 1382.6 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1034 (1030 residues), 759.5 bits, see alignment E=2.6e-232

Best Hits

Swiss-Prot: 69% identical to CUSA_ECOL6: Cation efflux system protein CusA (cusA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 78% identity to abo:ABO_1356)

MetaCyc: 69% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GIF8 at UniProt or InterPro

Protein Sequence (1054 amino acids)

>Psest_0596 heavy metal efflux pump (cobalt-zinc-cadmium) (Pseudomonas stutzeri RCH2)
MIAAIIRWSVANRFLILLATVFAVAWGVWSVKNTAVDALPDLSDVQVIIRTPYPGQAPRI
VENQVTYPLTTTMLSVPGAKTVRGYSFFGDSYVYVLFEDGTDLYWARSRVLEYLSQVQSR
LPAAAKPALGPDATGVGWIYQYALVDRTGKHDLSQLRSLQDWFLRYELKTLPNVAEVAPI
GGMVKQYQVVLDPVRMASRGVTQQQIAKAIDEANRETGGSVLELAETEFMVRATGYLKTL
KDFRAIPLRLDGGVPVTLGDVAHIQLGPEMRRGISELDGEGEVVGGVVILRSGKNARETI
AAVQTKLDELKASLPQGVEIVTTYDRSKLIDSAVENLTHKLIEEFIVVALVCAIFLWHLR
SSLVAIVSLPIGILIAFVIMQRQGINANIMSLGGIAIAIGAMVDAAIVMIENAHKHIEAW
HKRHPDSTLKGQEHWKVITDAAVEVGPALFFSLLIITLSFIPVFTLEAQEGRLFGPLAFT
KTYAMAAAAGLSVTLVPVLMGYWIRGKIPDEHRNPLNRGLIWIYKPALDAVLRWPKMTLL
VAVLVFLTGLWPASRLGGEFLPPLDEGDLLYMPTALPGLSAQKASELLQQTDRLIKTVPE
VAHVFGKAGRADTATDPAPLEMFETTIQFKPKDQWRPGMTPDKLVEELDRTVQVPGLANL
WIPPIRNRIDMLATGIKSPIGVKVYGTDLAQIDKATQAVEKIAKTVPGVSSALAERLTGG
RYIDVDIDRVAAARYGLNIADVQSIVAGAIGGQTIGETVEGLARYPINLRYGREWRDSIS
DLRNLPIYTPQGSQITLGTVAKVQVTDGPPMLKSENARLSGWVYVDVRGRDMAAVVGDLR
EKISKGVQLESGMSISYSGQFEFMERANAKLKLVVPATLLIIFVLLYLTFGRFGEALLIM
ATLPFALTGGVWFLYLLGYNLSVATGIGFIALAGVSAEFGVIMLLYLKNAWTDRVNAGAH
GEGVLLDAIREGAVQRVRPKAMTVAVIIAGLLPILWGSGTGSEIMSRIAAPMVGGMITAP
LLSLFVLPAAYLLMRRRQLRVTTQQATNPTGEHP