Protein Info for Psest_0583 in Pseudomonas stutzeri RCH2

Annotation: copper-resistance protein, CopA family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 613 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 2 to 611 (610 residues), 995.3 bits, see alignment E=9.2e-304 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 5 to 32 (28 residues), 21.8 bits, see alignment (E = 1.8e-08) PF07732: Cu-oxidase_3" amino acids 53 to 162 (110 residues), 132.1 bits, see alignment E=1.7e-42 amino acids 525 to 610 (86 residues), 28 bits, see alignment E=3e-10 PF00394: Cu-oxidase" amino acids 172 to 346 (175 residues), 89.2 bits, see alignment E=5e-29 PF07731: Cu-oxidase_2" amino acids 495 to 612 (118 residues), 100.5 bits, see alignment E=1e-32

Best Hits

Swiss-Prot: 76% identical to COPA_PSEUB: Copper resistance protein A (copA) from Pseudomonas syringae pv. tomato

KEGG orthology group: None (inferred from 85% identity to pmy:Pmen_2219)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GHE0 at UniProt or InterPro

Protein Sequence (613 amino acids)

>Psest_0583 copper-resistance protein, CopA family (Pseudomonas stutzeri RCH2)
MQRKTSRRTFVKGLTAAGILGGLGLWRAPVWAVTSPGQPSVLSGTEFDLLIGETPVNITG
AARTAMTINGTIPGPLLRWREGDTVTLRVRNKLSEDTSIHWHGMILPANMDGVPGLSFHG
IAPDGMYVYKFQVKQNGTYWYHSHSGLQEQLGVYGPLVIDAKDPEPFSYDRDYVVMLTDW
SDEDPARILSKLKKQSDYYNFHKRTVGDFINDVSEDGWAATIANRKMWAQMKMSPTDLAD
VSGYTYTYLMNGQAPDGNWTGIFKPGEKLRLRFINGSAMSYFDVRIPGLKMTVVAADGQY
VNPVSVDEFRIAVAETYDVIVEPATEEAYTIFAQSMDRTGYARGTLAVAEGLSAPVPETD
PRPLITMDDMGMDHGSMGGMAGMDHGGDMGAMDHSNMSGMNHGDMQGMGDMGAMAGMDHS
KMGGMSGMDHSGMAGMSAGMQSHPPSESNNPLVDMQTMSPTHRLNDPGIGLRDNGRRVLT
YSDLRSTFPDPDGREPSRTIELHLTGHMEKFSWSFDGIEFSDSEPLRLKYGERVRITLVN
DTMMTHPIHLHGMWSDLEDENGKFMVRKHTIDMPPGSKRSYRVTADALGRWAYHCHLLLH
MEMGMFREVRVDE