Protein Info for HP15_492 in Marinobacter adhaerens HP15

Annotation: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 371 PF00383: dCMP_cyt_deam_1" amino acids 5 to 102 (98 residues), 61.7 bits, see alignment E=8.3e-21 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 10 to 365 (356 residues), 384.6 bits, see alignment E=4.5e-119 PF14437: MafB19-deam" amino acids 27 to 117 (91 residues), 36.6 bits, see alignment E=5.7e-13 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 149 to 367 (219 residues), 190.5 bits, see alignment E=2.9e-60 PF01872: RibD_C" amino acids 150 to 363 (214 residues), 173.4 bits, see alignment E=7.9e-55

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 93% identity to maq:Maqu_0843)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.193

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PND8 at UniProt or InterPro

Protein Sequence (371 amino acids)

>HP15_492 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase (Marinobacter adhaerens HP15)
MIENRDRAMMARAVQLAWRGRYSTHPNPRVGCVIARGDLVLGEGWHERAGEAHAETRALS
QAGPDARGATAYVTLEPCSHFGRTPPCARALIDAGVAHVYAATKDPNPSVSGRGLDMLRE
AGIRVTEGLLAEEAARLNPGFMKRMNTGRPWVRLKMAASLDGRTAMASGESQWITGPEAR
RDVQRLRAISDAILTGVGTVLADDPSLTVRREELGDIGDATEPSRQPLRVIADRDARTPS
SAKILQGGNVQVFCASSTLATAPAQDLAALGISLTGVAWKDNGIDLAELLDSLGELGINE
LLVEAGPTLAGTFINENLVDELWLYQAPVFLGSTGRPTAHLPLETMADKVQWKVLDRRQV
GEDQRLILTRR