Protein Info for PGA1_c04920 in Phaeobacter inhibens DSM 17395

Annotation: l-lactate dehydrogenase IldD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 388 PF01070: FMN_dh" amino acids 15 to 376 (362 residues), 449.6 bits, see alignment E=7.3e-139

Best Hits

Swiss-Prot: 43% identical to LLDD_ACIAD: L-lactate dehydrogenase (lldD) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K00101, L-lactate dehydrogenase (cytochrome) [EC: 1.1.2.3] (inferred from 90% identity to sit:TM1040_0219)

Predicted SEED Role

"L-lactate dehydrogenase (EC 1.1.2.3)" in subsystem L-rhamnose utilization or Lactate utilization or Respiratory dehydrogenases 1 (EC 1.1.2.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.2.3

Use Curated BLAST to search for 1.1.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DM64 at UniProt or InterPro

Protein Sequence (388 amino acids)

>PGA1_c04920 l-lactate dehydrogenase IldD (Phaeobacter inhibens DSM 17395)
MPVITNINDLKRIYERRVPRMFYDYAESGSWTEQTFRDNTNDFEKIRLRQRVAVDMAGRS
TASQMIGQDVSMPVALAPVGLTGMQHADGEIKAARAAETFGVPFTLSTMSINSIEEVAEA
TTKPFWFQLYTMKDDDYVRRLIQRAKDARCSALVITLDLQILGQRHKDLKNGLSAPPKLT
PKTIANLMTKWSWGLQMLSAKRRNFGNIVGHVEGISDASSLGAWTAEQFDPSLDWSKIAK
LIELWDGKVILKGILDVEDAKMAAKLGADAIVVSNHGGRQLDGALSSIQMLPAIMDAVGD
QIEVHLDSGIRSGQDVLKALALGAKGTMIGRAFVYGLGAMGQHGVTRALEVLHKELDTTM
ALCGEKSVADLGRHNLLVPEDFGGRWQK