Protein Info for PGA1_c04900 in Phaeobacter inhibens DSM 17395

Annotation: peptidyl-tRNA hydrolase Pth

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 TIGR00447: aminoacyl-tRNA hydrolase" amino acids 1 to 163 (163 residues), 177.9 bits, see alignment E=8.6e-57 PF01195: Pept_tRNA_hydro" amino acids 3 to 182 (180 residues), 219.2 bits, see alignment E=2.1e-69

Best Hits

Swiss-Prot: 74% identical to PTH_RUEST: Peptidyl-tRNA hydrolase (pth) from Ruegeria sp. (strain TM1040)

KEGG orthology group: K01056, peptidyl-tRNA hydrolase, PTH1 family [EC: 3.1.1.29] (inferred from 74% identity to sit:TM1040_0214)

Predicted SEED Role

"Peptidyl-tRNA hydrolase (EC 3.1.1.29)" (EC 3.1.1.29)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.29

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DXP1 at UniProt or InterPro

Protein Sequence (252 amino acids)

>PGA1_c04900 peptidyl-tRNA hydrolase Pth (Phaeobacter inhibens DSM 17395)
MKLFVGLGNPGAKYAGNRHNIGFMALDQIASDHGFSPWKSKFQAQISEGVLGRTKVLLLK
PQTFMNLSGQSVGEAMRFYKLTPADVTVLHDELDLAPGKARVKQGGGHAGHNGLRSIHSH
IGADYGRVRLGIGHPGHKDAVAGYVLRDFAKADEAWLDDLMRGISDGAAQLAAGDGGKFM
NAVALRVAPPRSSSGSGAAAKGRTDAPSSKKAAQPDRSDAQKTPPIAAEPSAVQSADETA
PSAIERLLNKFK