Protein Info for HP15_p187g91 in Marinobacter adhaerens HP15

Annotation: protein containing chemotaxis methyl-accepting receptor, signaling, PAS fold protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 TIGR00229: PAS domain S-box protein" amino acids 1 to 82 (82 residues), 40 bits, see alignment E=1.9e-14 amino acids 78 to 204 (127 residues), 83.6 bits, see alignment E=6.3e-28 amino acids 208 to 323 (116 residues), 51.3 bits, see alignment E=6.4e-18 PF00989: PAS" amino acids 83 to 194 (112 residues), 45.6 bits, see alignment E=2e-15 amino acids 213 to 312 (100 residues), 49.2 bits, see alignment E=1.5e-16 PF13188: PAS_8" amino acids 84 to 134 (51 residues), 29.9 bits, see alignment 1.1e-10 PF08448: PAS_4" amino acids 88 to 199 (112 residues), 24.1 bits, see alignment E=1.1e-08 amino acids 216 to 322 (107 residues), 41.4 bits, see alignment E=4.5e-14 PF13426: PAS_9" amino acids 93 to 197 (105 residues), 43.8 bits, see alignment E=7.9e-15 amino acids 217 to 320 (104 residues), 75.9 bits, see alignment E=8e-25 PF08447: PAS_3" amino acids 228 to 314 (87 residues), 29.3 bits, see alignment E=2.6e-10 PF00015: MCPsignal" amino acids 439 to 532 (94 residues), 121.9 bits, see alignment E=7.9e-39

Best Hits

Predicted SEED Role

"Heme-regulated cyclic AMP phosphodiesterase (EC 3.1.4.-)" in subsystem Putative hemin transporter or cAMP signaling in bacteria (EC 3.1.4.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.4.-

Use Curated BLAST to search for 3.1.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PS53 at UniProt or InterPro

Protein Sequence (541 amino acids)

>HP15_p187g91 protein containing chemotaxis methyl-accepting receptor, signaling, PAS fold protein (Marinobacter adhaerens HP15)
MLGENVKILVPASVKDHHDAHIEHNRQGGSDRIVGTSRDVCMERKDGSQVWVNLALNKVV
SGRSITYTAFVRDITAERASREMINQTLEQALDAVVTIDENNVIIFVNSAAEHLWGYDRQ
EMLGNNVKMLVPHDIQGRHDEMVNANRRTGVDKIVGTSREVPVFRKDGARRWATLALSKI
QLDDRILYTAFLKDVTEEVERRNEFRMLSMVANETDNAVIITTPDRKIVYVNRGFTQLTG
YGLDEVVGKNPGDFLQGPHTDPETIDQIRQKLRHHQPFYDEVLNYDRNQKPYWVSLAINP
VFDESGTLTHYISIQANVTETKEKSLEYTRRFEAISDSNGVTEWGLDGSLWHCNAYMLRS
LGDGSAEQTKARIKNLKEIIGTDKFNTLLGGSQISGSFAFPDADNQAHWFDVTVCPIADF
SGSIKYFVAYGIDVHSKMQAVQVTDEEMKSVLKSSDEISQIVSAINQIAEQTNLLALNAA
IEAARAGEAGRGFAVVADEVRQLAQKSGQSADEINRLVTETNNRIESLAESLRALNDISQ
E