Protein Info for HP15_p187g40 in Marinobacter adhaerens HP15

Annotation: GGDEF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 PF00563: EAL" amino acids 35 to 257 (223 residues), 140.6 bits, see alignment E=2.7e-45

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PS02 at UniProt or InterPro

Protein Sequence (291 amino acids)

>HP15_p187g40 GGDEF family protein (Marinobacter adhaerens HP15)
MFDAPGTKGMTDYPMGKAGTYDDLGPAARSALHSILFQPKVDLSTKRYCGVEALSRWQPD
QTQPPWLQTRGGVSVPDTDEHCQAYDYVVLSSVLNLCGRWSPALRSKAGTVSVNITGPTL
SSAWLAPFIKRCLSTRGLPRLTIELTETFAITNETSALKTMQTLSRYGVAFSIDDFLTGF
NQQPIFARLPFEELKVDRQDVQNLSTKRGSALVAQIVSSAKARGATVVAEGIENPAQLEL
AKASGCAQGQGFCISQPLTESDFVNRLAQPGDHPWAATEFEHAQKEKTQQL