Protein Info for HP15_4151 in Marinobacter adhaerens HP15

Annotation: GGDEF domain-like protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 397 PF08447: PAS_3" amino acids 134 to 214 (81 residues), 36.5 bits, see alignment E=7.1e-13 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 232 to 394 (163 residues), 161 bits, see alignment E=1e-51 PF00990: GGDEF" amino acids 236 to 391 (156 residues), 146.4 bits, see alignment E=1e-46

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PMK7 at UniProt or InterPro

Protein Sequence (397 amino acids)

>HP15_4151 GGDEF domain-like protein (Marinobacter adhaerens HP15)
MRWDATTEKVLVNEAFHGLLGPSKRGTEINLSELMTPQDIARLLEKLDPKRPPMAHDHGT
FLCRLIGSDEQILWLETTVCESSAKEGISCRYATFKDVTDRLTKELFFENFADSLPGIVF
SYTVYPDSSHYFSYISIKTKEFFGIENREFLANPDLAFDIIEPEDLPFVRESLAESKRTM
THWKAEYRTTVKGKTRWFEGTAIPKLQPNGSVTWNGITIAIDDRKNLELELKEVASKDYL
TGVFNRRYLSEFLRDQSERFDRYQERSSVILIDIDNFKAINDEHGHDFGDLVLRQFSDLV
SKNVRKVDTFGRMGGEEFLIILPNTGVQSALEVGKKILRKTRSKLQTIDGIDVALTFSAG
ISEFSAVQSSANKVLKHADQLLYEAKSEGRNGIKTDG