Protein Info for Psest_0398 in Pseudomonas stutzeri RCH2

Annotation: NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 581 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 31 to 54 (24 residues), see Phobius details amino acids 60 to 78 (19 residues), see Phobius details amino acids 92 to 114 (23 residues), see Phobius details amino acids 121 to 141 (21 residues), see Phobius details amino acids 164 to 183 (20 residues), see Phobius details amino acids 187 to 212 (26 residues), see Phobius details amino acids 222 to 256 (35 residues), see Phobius details amino acids 270 to 290 (21 residues), see Phobius details amino acids 298 to 323 (26 residues), see Phobius details amino acids 335 to 356 (22 residues), see Phobius details amino acids 363 to 386 (24 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 20 to 388 (369 residues), 202.6 bits, see alignment E=1.4e-63 PF02080: TrkA_C" amino acids 418 to 483 (66 residues), 51.8 bits, see alignment E=9.2e-18 PF03471: CorC_HlyC" amino acids 496 to 569 (74 residues), 46.2 bits, see alignment E=5.5e-16

Best Hits

Swiss-Prot: 97% identical to NHAP2_PSEU5: K(+)/H(+) antiporter NhaP2 (nhaP2) from Pseudomonas stutzeri (strain A1501)

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 97% identity to psa:PST_3879)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0GI90 at UniProt or InterPro

Protein Sequence (581 amino acids)

>Psest_0398 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain (Pseudomonas stutzeri RCH2)
MDLGNLNHLFFIGALLVAASILMSSLSNRLGVPILVIFLAVGMLAGVDGVGGIVFGDYQL
AFIISNLALAVILLDGGMRTRTATFRVALKPAFSLATLGVAITSGLTGLAAAWLFDLPLL
QGLLIGAIVGSTDAAVVFNLLNGKGLNERVGSTLEIESGSNDPMAMFLTVALIDMLLAGR
TTFGWDFLLTLLQQFGIGTVLGLLGGWLLLQLINRLSVADGLYPLLAVAGGLMIFALSGA
IGGSGILAIYVCGLLLGNRPIRNRHGILHMFDGLAWLSQISMFLVLGLLLTPSELLPIAL
PALALSLWMILFARPLAVFVSLLPFRSFHLRERLFISWIGLRGAVPVILAVFPLMAGLEN
AQLFFNVAFFIVLVSLLLQGSTLAWAAKKAKVEVPPSPMPVSRSGLQVHTTSQWEMFVYR
LSASKWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLQVDDILCVIGHDEDLPALG
KLFSQAPTRGQDLRFFGDFILEADAQLSAIAALYGLKLREVDGNQTIGAFMAEQVSGNPV
VGDQVEWNGLTWTVAAMEAGEVRKVGLKFPEGDKPGPQLMF