Protein Info for HP15_3863 in Marinobacter adhaerens HP15

Annotation: GGDEF domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 42 to 61 (20 residues), see Phobius details amino acids 75 to 96 (22 residues), see Phobius details amino acids 103 to 124 (22 residues), see Phobius details amino acids 138 to 159 (22 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details amino acids 215 to 237 (23 residues), see Phobius details PF03707: MHYT" amino acids 2 to 30 (29 residues), 21.8 bits, see alignment (E = 1.5e-08) amino acids 51 to 106 (56 residues), 54.3 bits, see alignment 1.1e-18 amino acids 116 to 161 (46 residues), 45.6 bits, see alignment 5.5e-16 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 257 to 398 (142 residues), 45.7 bits, see alignment E=2.8e-16 PF00990: GGDEF" amino acids 259 to 398 (140 residues), 64.4 bits, see alignment E=1.1e-21

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJ29 at UniProt or InterPro

Protein Sequence (428 amino acids)

>HP15_3863 GGDEF domain protein (Marinobacter adhaerens HP15)
MMSEYDLPLVVASFLVAVLAAYAALFFGARLVNAESGERRKWLLAGALLMGTGVWTMHFV
GMRAMPMGVPMSFDVMMTLVSWLAAVFASGVALHIIGRKQLGVPLFVSATLSMASGIVVM
HYLGMYAMRMSAPPTFNTVFLLISIAIAVVASGAALALCRKLQGMDGSGTLAVQFVAALV
MAAAICGMHYTGMMAMTFPEGAVPAADNGLRGNWMGIPLAVFCIAMLAVALVVTVLDVKH
QRALEEFKAEEDKRVAELAFTDAVTGLPNRSALEQRLLDILARDNDRGNPFALIYLDIAN
FRELATGMGDESLNAVVREISEALRDQMSDQVFLARYSASAFFALVPDHEDSQHAFMYKR
LRQIDQRIGTPSMPVTWRAGQAAYPKTGNSTRKLVRAAMVPRDLNEIGEFANMAADPELV
MPGHNRHS