Protein Info for HP15_3792 in Marinobacter adhaerens HP15

Annotation: D-(-)-3-hydroxybutyrate oligomer hydrolase precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 725 signal peptide" amino acids 1 to 45 (45 residues), see Phobius details PF10605: 3HBOH" amino acids 45 to 725 (681 residues), 863.5 bits, see alignment E=5.8e-264

Best Hits

Swiss-Prot: 79% identical to HBOH_MARHV: D-(-)-3-hydroxybutyrate oligomer hydrolase (Maqu_0083) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K07518, hydroxybutyrate-dimer hydrolase [EC: 3.1.1.22] (inferred from 79% identity to maq:Maqu_0083)

Predicted SEED Role

"D(-)-3-hydroxybutyrate oligomer hydrolase (EC 3.1.1.22)" in subsystem Polyhydroxybutyrate metabolism (EC 3.1.1.22)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PI70 at UniProt or InterPro

Protein Sequence (725 amino acids)

>HP15_3792 D-(-)-3-hydroxybutyrate oligomer hydrolase precursor (Marinobacter adhaerens HP15)
MRMAFPGPGLRPGLFVYNNKQGTIMKRIMLCALIGATGLTLSACKDNPPFNEIPDFIQGD
ISQTSYDGITDDLLTAGLGASGLASAPGPAFADPLNPTAAELRRLAIYNNYRALVDTAPG
GGYGTFFGPQVNASGEGLIAGDEFIAYMSVPGTDVPVTVMAQVPDSFDPDRPCMVTAPSS
GSRGIYGAIGTAGEWGLKKGCAVVYTDKGTGTGSHNLATNTAQRIDGTLTSDVEPVQFRA
DLTDGQRADFDSAWPDRFAWKHAHSRANPEADWGQHVLQSIEFGFYVLNEKFGRELGNGE
TLLTIKPKNTVVIASSVSNGGGSSVRAAEQDTKGLIDGVAVSEPNVNPQVDRSFTIRQGE
GPEITEHSRSLLDYTTALAVYQGCANQAPAIRDDAPLNATFNPPAIGENICNSLANKGLV
SGATLDDRATDALRILNEDFGIQPEQNLLAPVHFGLAVAQSISMTYANAYGRAGVEDRVC
ELSLAATDSAGAVTQLAPAAEAALFSASNGIPPSAGVNIVYDGADGQPTNLPASASPSTN
QLDYGLDALLCLRSLAQGSDAVSGADLQGSDAELATAIAEGIAEVRASGDLQGKPTVFVT
GRADAILPINHTSRPYFGLNQRVEGKKSNLRYYEILNAHHLDVLNGFPGVADRYVPLHHY
YFQALDLVWANLTEKQALPPSQVVRTVPRGAITTPLAEVNLPAINPAPDAGDRIVFTDNQ
VRIPE