Protein Info for HP15_3770 in Marinobacter adhaerens HP15

Annotation: MATE efflux family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 45 to 66 (22 residues), see Phobius details amino acids 87 to 109 (23 residues), see Phobius details amino acids 134 to 154 (21 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 191 to 211 (21 residues), see Phobius details amino acids 241 to 260 (20 residues), see Phobius details amino acids 266 to 293 (28 residues), see Phobius details amino acids 315 to 338 (24 residues), see Phobius details amino acids 356 to 375 (20 residues), see Phobius details amino acids 386 to 403 (18 residues), see Phobius details amino acids 409 to 430 (22 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 18 to 411 (394 residues), 254.6 bits, see alignment E=7.6e-80 PF01554: MatE" amino acids 18 to 178 (161 residues), 91.6 bits, see alignment E=2.3e-30 amino acids 251 to 394 (144 residues), 52.6 bits, see alignment E=2.2e-18

Best Hits

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 86% identity to maq:Maqu_0061)

Predicted SEED Role

"DNA-damage-inducible protein F"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PI48 at UniProt or InterPro

Protein Sequence (442 amino acids)

>HP15_3770 MATE efflux family protein (Marinobacter adhaerens HP15)
MTFNLPATDRRLWALAWPLMLTNLTVPLLGLVDTAVLGHLESPEFLGAVAVGANLFSILY
WTFGFMRMGTTGLAAQAWGKRDNFSQVALLLRSILLATGIGLLLILFHQPLIQTGLSLMN
PSDNVTELAAEYAGIRIWSAPAVLCQYTLVGWLIGTQFPRGPMIMLIAANGLNIVLDILF
VTVLGWNSRGVAIATVIAEYGAAAIGFLIVLRRMPEGQGLTRALFGKLEDYLRILRVNRY
IMVRTIALLLVLAFFTAQGARQGDTILAANAVLITFLLLISNALDGFANAAEALIGEAIG
KGSRRRFRVVFRSALRWSLWGALLLTIVFVAGGHWLIALLTGIEEVRATAWRYLPWLWLL
PFAAVWGFLLDGIFIGATRTRDMQNTMLFSALAVFAPVWWLTTGWGNHGLWFALISLMVA
RALSMGWLCWSHTRNDRWFQSQ