Protein Info for HP15_3702 in Marinobacter adhaerens HP15

Annotation: chromosomal replication initiation protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 480 PF11638: DnaA_N" amino acids 2 to 60 (59 residues), 71.8 bits, see alignment E=7.8e-24 TIGR00362: chromosomal replication initiator protein DnaA" amino acids 2 to 477 (476 residues), 602.5 bits, see alignment E=2.8e-185 PF00308: Bac_DnaA" amino acids 145 to 362 (218 residues), 320.1 bits, see alignment E=2.2e-99 PF01695: IstB_IS21" amino acids 181 to 280 (100 residues), 29.9 bits, see alignment E=1e-10 PF00004: AAA" amino acids 182 to 285 (104 residues), 24.6 bits, see alignment E=7.4e-09 PF08299: Bac_DnaA_C" amino acids 389 to 457 (69 residues), 110.3 bits, see alignment E=9.1e-36

Best Hits

Swiss-Prot: 91% identical to DNAA_MARHV: Chromosomal replication initiator protein DnaA (dnaA) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K02313, chromosomal replication initiator protein (inferred from 91% identity to maq:Maqu_0001)

Predicted SEED Role

"Chromosomal replication initiator protein DnaA" in subsystem DNA-replication

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PHG5 at UniProt or InterPro

Protein Sequence (480 amino acids)

>HP15_3702 chromosomal replication initiation protein (Marinobacter adhaerens HP15)
MWHQCLEVLRDEFPAQQFNTWLRPLQSDHREGQLMLFAPNRFVMDWVNEKYLRRIEEVLK
DLNGGQAPRVNMKVGSAPREGEPVKRSEAPARVNGQVQEEAGSRVTEEEKGVAATVASTP
SVRPKSDTQRRPVQVEGDIKHQSFLNEGFTFETFVEGKSNQLARAASMQVAENPGGAYNP
LFLYGGVGLGKTHLMHAIGNEIVRRNPKAKVAYLRSERFVADMVKALQLNAINEFKRYYR
SVDALLIDDIQFFARKERSQEEFFHTFNALLEGGQQVIVTCDRFPKEIVDMEERLKSRFG
WGLTVMVEPPELETRVAILMKKADQANVKLSSEAAFFIAQKIRSNVRELEGALRLVIANA
HFTGSEITPPFIRESLKDLLALHEKQVSIDNIQRTVAEYYKIKVADLLSKRRTRTVTRPR
QVAMALSKELTNHSLPEIGDAFGGRDHTTVLHACKKIVELQETDPGIREDYQNFMRLLTT