Protein Info for HP15_3631 in Marinobacter adhaerens HP15

Annotation: diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 866 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 189 to 207 (19 residues), see Phobius details amino acids 214 to 234 (21 residues), see Phobius details amino acids 247 to 270 (24 residues), see Phobius details amino acids 279 to 300 (22 residues), see Phobius details amino acids 306 to 328 (23 residues), see Phobius details amino acids 335 to 356 (22 residues), see Phobius details amino acids 368 to 386 (19 residues), see Phobius details PF07696: 7TMR-DISMED2" amino acids 39 to 173 (135 residues), 116.6 bits, see alignment E=1.7e-37 PF07695: 7TMR-DISM_7TM" amino acids 185 to 388 (204 residues), 156.8 bits, see alignment E=1.5e-49 PF00990: GGDEF" amino acids 422 to 580 (159 residues), 53 bits, see alignment E=7.1e-18 PF00563: EAL" amino acids 608 to 841 (234 residues), 238.4 bits, see alignment E=1.5e-74

Best Hits

KEGG orthology group: None (inferred from 67% identity to maq:Maqu_3844)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PGT6 at UniProt or InterPro

Protein Sequence (866 amino acids)

>HP15_3631 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) (Marinobacter adhaerens HP15)
MILSTALRIFLLSLATFTSQFAHADSAPVTLASEKPIESHFQYWEDASAEAELADVRALP
DAAWQTNPSGKATFGITDSAYWLRVEVQNQTGRDQLLIAELGYSQFDDVVFHELSGGTLL
REFATGDTRPFYPRDVDHPNMLYRFHVAPDASKTLYIRVATQGTMVVPLQIWQQNDFYEA
AANEQKLHFFYYGSLAVIILINLAVFLTLREKLYLYYALAISGYFLFFAAVRGYTLQHIY
PGAPFLHTHVLLLSMPFLAMFSILFCMEFLQVRSNSPRLYRALQAMLLFEMLFFLSAPML
DYDTGIRVAAVSAFAFFSLLLVAGPVAWAAGVRAGVFFTIAWTPLTIGVSATAGRALGLL
PENFFTEYAMQIGSGLEAFILTLALADRLYREREQKIQAQADILKQQKARNEAQTQLNEA
LTHDPVTGLPNRNRFEWMVDEQLRQNPNGRFMVGVTRITQLKEINRTLGLDRSERLLKAM
AEQMTRLASGLPMVHHTVDARGNDERVYQLSGDSFGLLVNVSKTADDFQSLDNALKQLAE
PVLLDNIAIEPNPRFGAASYPEHGKKAALLIRNAHVGMEMAPHGPYQTGLYSRKDDIYDE
SRLTLMSDLREALHHNQTELYYQPKISLATGKVVGVEALIRWHHPDRGWVPPIEFVPMAE
KTGVIKHLTRWVVDQALNDLKELHALDPALTVSVNISARDLSSPELVGLFETRTKRNQLN
PEQVIIELTETAAMDDPHRGLSALNELTAIGLKLSIDDFGAGYSSLSYLKKLPASEIKLD
RALLQDIESSEGARMIVETAIRMGQGLGYQVVAEGVETEKSARLLNQLGAEMLQGYWICS
PKPLHELQAWLEVERKAPSLQGLQQV