Protein Info for HP15_3566 in Marinobacter adhaerens HP15

Annotation: MATE efflux family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 58 to 76 (19 residues), see Phobius details amino acids 88 to 112 (25 residues), see Phobius details amino acids 133 to 153 (21 residues), see Phobius details amino acids 165 to 185 (21 residues), see Phobius details amino acids 192 to 211 (20 residues), see Phobius details amino acids 247 to 271 (25 residues), see Phobius details amino acids 277 to 297 (21 residues), see Phobius details amino acids 312 to 335 (24 residues), see Phobius details amino acids 354 to 375 (22 residues), see Phobius details amino acids 382 to 401 (20 residues), see Phobius details amino acids 407 to 429 (23 residues), see Phobius details PF01554: MatE" amino acids 20 to 180 (161 residues), 81.9 bits, see alignment E=4.4e-27 amino acids 239 to 400 (162 residues), 56.6 bits, see alignment E=2.6e-19 TIGR00797: MATE efflux family protein" amino acids 20 to 402 (383 residues), 185.3 bits, see alignment E=9e-59 PF14667: Polysacc_synt_C" amino acids 149 to 264 (116 residues), 32 bits, see alignment E=1.3e-11

Best Hits

KEGG orthology group: None (inferred from 75% identity to maq:Maqu_3799)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PGM1 at UniProt or InterPro

Protein Sequence (445 amino acids)

>HP15_3566 MATE efflux family protein (Marinobacter adhaerens HP15)
MQTTTQNPSLARQLYSMTWPMLFGVLSLMTFQLADSAFVGQLGRDPLAALGFTLPMQQLI
IGLQVGLGIATTAIVSRTLGAGDELRAFRLGGLIITVGGSLVFVICMALWFLQSHIMTAL
GAEDSLLPLVRQYWVPWLMAAWTGAFLYFGYSVCRSHGDTKLPGYMMVATSLTNIALDPL
YIFVFGWGLPGAAWATITSFGIGCLVIYPKLLKRHWIRFDLRELALWKALKQLNGIMAPA
MVSQLMPAVSAMLATALVAGFGSAAVAAWGLGTRLEFFSIVVVLALTMSMPPMIGRMLGA
GDIEQIRKLVRLAVRFVVVWQLAIGLTWVVASGLVSELFSSDSDVQEVLAGYLVRVPLSY
SGLGVCMLMVSVCNALGLAMRALLVSTLRLFLCFLPLLWIGSQINGVYGLMSGALVGNLF
AGAMAYSFYRAGMTRLKAEISSGKA