Protein Info for PGA1_c03630 in Phaeobacter inhibens DSM 17395

Annotation: succinyl-CoA ligase [ADP-forming] subunit beta

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01016: succinate-CoA ligase, beta subunit
  • amino acids 1 to 395 (395 residues), 523.1 bits, E=2.1e-161
• PF08442: ATP-grasp_2
  • amino acids 2 to 212 (211 residues), 243.6 bits, E=2.3e-76
• PF13549: ATP-grasp_5
  • amino acids 4 to 226 (223 residues), 31.4 bits, E=1.9e-11
• PF00549: Ligase_CoA
  • amino acids 272 to 391 (120 residues), 125.2 bits, E=2.8e-40

Best Hits

Swiss-Prot: 88% identical to SUCC_JANSC: Succinate--CoA ligase [ADP-forming] subunit beta (sucC) from Jannaschia sp. (strain CCS1)

KEGG orthology group: K01903, succinyl-CoA synthetase beta subunit [EC: 6.2.1.5] (inferred from 93% identity to rde:RD1_1615)

MetaCyc: 56% identical to 3-sulfinopropionyl-CoA synthetase beta subunit (Advenella mimigardefordensis DPN7)
Succinate--CoA ligase (ADP-forming). [EC: 6.2.1.5]; 6.2.1.- [EC: 6.2.1.5]

Predicted SEED Role

"Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5)" in subsystem Serine-glyoxylate cycle or TCA Cycle (EC 6.2.1.5)

MetaCyc Pathways

• TCA cycle III (animals) (9/10 steps found)
• adipate degradation (5/5 steps found)
• methylaspartate cycle (15/19 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (20/26 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (17/22 steps found)
• TCA cycle I (prokaryotic) (8/10 steps found)
• TCA cycle VIII (Chlamydia) (5/6 steps found)
• TCA cycle II (plants and fungi) (7/9 steps found)
• TCA cycle V (2-oxoglutarate synthase) (7/9 steps found)
• adipate biosynthesis (4/5 steps found)
• superpathway of glyoxylate bypass and TCA (9/12 steps found)
• pyruvate fermentation to acetate V (2/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• reductive TCA cycle I (7/11 steps found)
• incomplete reductive TCA cycle (4/7 steps found)
• pyruvate fermentation to acetate VI (1/3 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
• 3,3'-disulfanediyldipropannoate degradation (1/4 steps found)
• reductive TCA cycle II (5/12 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (21/56 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• C5-Branched dibasic acid metabolism
• Citrate cycle (TCA cycle)
• Propanoate metabolism
• Reductive carboxylate cycle (CO2 fixation)

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.5

Use Curated BLAST to search for 6.2.1.5

Sequence Analysis Tools

See I7ETR6 at UniProt or InterPro

Protein Sequence (397 amino acids)

>PGA1_c03630 succinyl-CoA ligase [ADP-forming] subunit beta (Phaeobacter inhibens DSM 17395)
MNIHEYQAKALLRSYGAPVSDGRVVLKAEDAKTAAGELDGPLWVVKAQIHAGGRGKGSFK
EADAGEKGGVRLTKSVEEAADEAKKMLGRTLVTHQTGPAGKQVNRIYIEAGSGIQTELYL
ALLVDRQTSRVSFVCSTEGGMDIEEVAEATPEKILSFSVDPATGYQAFHGRRIAFSLGLE
GQQIKQCVRLMGQLYKAFVEKDMEMLEINPLIVSDSGDLKVLDAKVGFDGNAVYRHADIS
ELRDTTEEDPKELEASKYDLNYIALDGEIGCMVNGAGLAMATMDIIKLYGAEPANFLDVG
GGATKEKVTEAFKIITSDPNVKGILVNIFGGIMRCDVIAEGVVAAVKEVGLKVPLVVRLE
GTNVEAGKDIINTSGLDVIAADNLSDGAEKIVKAVKG