Protein Info for PGA1_c35520 in Phaeobacter inhibens DSM 17395

Annotation: HemY-like protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 507 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 47 to 71 (25 residues), see Phobius details PF07219: HemY_N" amino acids 30 to 143 (114 residues), 88.4 bits, see alignment E=4.8e-29 PF14559: TPR_19" amino acids 327 to 381 (55 residues), 30.1 bits, see alignment 7.3e-11

Best Hits

KEGG orthology group: K02498, HemY protein (inferred from 78% identity to sit:TM1040_2826)

Predicted SEED Role

"Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7ES53 at UniProt or InterPro

Protein Sequence (507 amino acids)

>PGA1_c35520 HemY-like protein (Phaeobacter inhibens DSM 17395)
MLWSLLKILVFVAIVAVLAFGAALLTETAGGVQITVAGTEYTLSALQSVIALAILVFVVW
VLFKLLSLLLATLRFLNGDETAISRYFDKGRERKGYQALSDGLMALASGEGRLAMAKAAR
AEKYLEKPELTDLLTAQAAELAGDTKKAAEAYKRLVSNQSTRFVGVRGIMKQKLSEGDTD
TARQLAEKALSLRPKHEEVQDTLLTLQARAQDWAGARKTLTTKLKTGTLPRDVYKRRDAV
LALSASKAIVKEGATVEQQEQAIEANRLSPDLVPAAAMAARAYLARDKKRYAIRVLKKAW
EAQPHPDLAHAFAEVEPTETAQERVKRFAQLSRLAPQHDETRLVMAELHIVAEDFPEARR
ALGDLVEREPDARALTLMAAIEKGEGASDAVIQGWLARALNAPRGPQWVCGNCNHIHAEW
APVCENCASFDTLSWRRPEAPEIVGATGAQVLPLITGTPEGAAGPDASDIPEVELLEEED
TSVSDVGETLPQGPDTGGGDAKTQSIK