Protein Info for PGA1_c03600 in Phaeobacter inhibens DSM 17395

Annotation: 2-oxoglutarate dehydrogenase E1 component SucA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 985 PF16078: 2-oxogl_dehyd_N" amino acids 13 to 52 (40 residues), 58.5 bits, see alignment (E = 7.7e-20) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 99 to 980 (882 residues), 1100.6 bits, see alignment E=0 PF00676: E1_dh" amino acids 240 to 560 (321 residues), 184.2 bits, see alignment E=5.7e-58 PF02779: Transket_pyr" amino acids 629 to 822 (194 residues), 162.7 bits, see alignment E=1.4e-51 PF16870: OxoGdeHyase_C" amino acids 827 to 981 (155 residues), 182.3 bits, see alignment E=1e-57

Best Hits

Swiss-Prot: 64% identical to ODO1_BRUC2: 2-oxoglutarate dehydrogenase E1 component (sucA) from Brucella canis (strain ATCC 23365 / NCTC 10854)

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 66% identity to bbt:BBta_0395)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DXB0 at UniProt or InterPro

Protein Sequence (985 amino acids)

>PGA1_c03600 2-oxoglutarate dehydrogenase E1 component SucA (Phaeobacter inhibens DSM 17395)
MTDQSPNELFHASSFMQGHNAEYLEQLYAQYANDPNAVDAAWAEFFRQMGDAELDVKAEA
AGPSWARADWPPAPNDDLTGALTGEWPAPAEAKGAGKKIKEQAAAKGVEVTDDQVQRAVL
DSIRALMLIRAYRIRGHLAANLDPLGMREEAQHPELDPRTYGFTEADMDRPIFIDNVLGL
QVASMRQIVSIVKRTYCGTFALQYMHISDPEQASWLKERIEGYDKEITFTREGRKAILNK
MVEAEGFEKFLHVKYMGTKRFGLDGGESLIPAMEQIIKRGGALGIRDIVIGMPHRGRLSV
LANVMQKPYKAIFNEFQGGSFKPEDVDGSGDVKYHLGASSDREFDGNSVHLSLTANPSHL
EAVNPVVLGKVRAKQDQLKDSERTKVLPILLHGDAAFAGQGVVAECFALSGLRGHKAGGT
MHIVVNNQIGFTTAPHFSRSSPYPTDNALVVEAPIFHVNGDDPEAVVHAARVATEFRQKF
HKDVVLDIFCYRRFGHNEGDEPMFTNPLMYKKIKGHKTTLSLYTERLVKDGLIPEGEIED
MKASFQARLNEEFEAGKNFKPNKADWLDGRWSHLDKKDTDYQRGQTSVSPETFKEVGTAL
SRVPEGFPVHKTIGRFLDARAKMVDSGEGIDWATGEALAFGSLLTEGYPVRLSGQDATRG
TFSQRHSGIVNQNTEERYYPLNNIRSGQSHYEVIDSALSEYAVLGFEYGYSLAEPNALTL
WEAQFGDFANGAQIMFDQFISSGESKWLRMSGLVCLLPHGFEGQGPEHSSARLERFLQMC
GQDNWIVANCTTPANYFHILRRQLHRTFRKPLIMMTPKSLLRHKLAVSKAEEFTTGSSFH
RVLWDDAQHGNSDTKLVADDKIKRVVLCSGKVYYDLLEERDARGLDDVYLMRIEQYYPFP
AISLVKELERFKGAEVVWCQEEPKNQGAWSFIEPNIEWVLTRIGAKHSRPTYVGRATSAS
PATGLASEHKAQQAALVNEALSIEG