Protein Info for HP15_3315 in Marinobacter adhaerens HP15
Annotation: acetylornithine deacetylase (ArgE)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 52% identical to ARGE_PROMH: Acetylornithine deacetylase (argE) from Proteus mirabilis (strain HI4320)
KEGG orthology group: K01438, acetylornithine deacetylase [EC: 3.5.1.16] (inferred from 88% identity to maq:Maqu_3558)MetaCyc: 50% identical to acetylornithine deacetylase (Escherichia coli K-12 substr. MG1655)
Acetylornithine deacetylase. [EC: 3.5.1.16]
Predicted SEED Role
"Acetylornithine deacetylase (EC 3.5.1.16)" in subsystem Arginine Biosynthesis extended (EC 3.5.1.16)
MetaCyc Pathways
- L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
- superpathway of arginine and polyamine biosynthesis (14/17 steps found)
- L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
- L-ornithine biosynthesis I (5/5 steps found)
KEGG Metabolic Maps
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Urea cycle and metabolism of amino groups
Isozymes
No predicted isozymesUse Curated BLAST to search for 3.5.1.16
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E4PRI2 at UniProt or InterPro
Protein Sequence (389 amino acids)
>HP15_3315 acetylornithine deacetylase (ArgE) (Marinobacter adhaerens HP15) MSQSDSKSAVVPGIRDMLARLISLPSISSASAKWDHSNEPVVRTLAEWLEALGFSVEILE VPGMPGKFNLIGTLGSGPGGLVLSGHTDTVPFDDKRWQSDPFTLTERDNRWYGLGTCDMK GFFPLAIEAARAFVDEDLKQPLIILATADEESSMDGARALAEAGKPKARYAVIGEPTSLK PVRMHKGIMMERLKFEGQSGHSSNPALGRNAMEGMHEALTELLALRSGWQEKYRNPNFEV QFPTLNLGCIHGGDNPNRICAQCELHFDLRPLPGMNMETLRQAILSKVQPIADRRELSLE FEPLFDGVPPFETPADAALVKACEKLTGHTAHAVAFATEAPWLQKLGLETLVMGPGSIDQ AHQPDEFIELSQIDPTVKVLRGLIRQFCL