Protein Info for HP15_3293 in Marinobacter adhaerens HP15

Annotation: glutathione S-transferase, N-terminal domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02798: GST_N
  • amino acids 2 to 75 (74 residues), 46.7 bits, E=9.7e-16
• PF13417: GST_N_3
  • amino acids 6 to 82 (77 residues), 46.3 bits, E=1.3e-15
• PF13409: GST_N_2
  • amino acids 10 to 77 (68 residues), 57.4 bits, E=5.4e-19
• PF13410: GST_C_2
  • amino acids 131 to 196 (66 residues), 36.4 bits, E=1.4e-12
• PF00043: GST_C
  • amino acids 134 to 201 (68 residues), 37.2 bits, E=8.5e-13
• PF14497: GST_C_3
  • amino acids 136 to 202 (67 residues), 31.4 bits, E=5.7e-11

Best Hits

KEGG orthology group: None (inferred from 83% identity to maq:Maqu_3536)

Predicted SEED Role

"Glutathione S-transferase (EC 2.5.1.18)" in subsystem Glutathione: Non-redox reactions (EC 2.5.1.18)

MetaCyc Pathways

• 4-hydroxy-2-nonenal detoxification (1/4 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• pentachlorophenol degradation (3/10 steps found)
• gliotoxin biosynthesis (1/9 steps found)
• glutathione-mediated detoxification II (1/9 steps found)
• indole glucosinolate activation (intact plant cell) (3/12 steps found)
• camalexin biosynthesis (2/12 steps found)

KEGG Metabolic Maps

• Drug metabolism - cytochrome P450
• Glutathione metabolism
• Metabolism of xenobiotics by cytochrome P450

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.18

Use Curated BLAST to search for 2.5.1.18

Sequence Analysis Tools

See E4PR00 at UniProt or InterPro

Protein Sequence (205 amino acids)

>HP15_3293 glutathione S-transferase, N-terminal domain protein (Marinobacter adhaerens HP15)
MKIFETKTAPNPRRVRMFMAEKGLLEKAEFIEIDLQKGENLTPEFVARNPMKKVPVMELD
DGTCIAETMAICRYFEESYPDTPTLMGDTPLEKAQLEQWLRWIELFFFMPTGMCFQHTTG
YFKDRMNPIKEWGEECGKSVEKFMHFLDKQLEGKEYICCDRFTAADINAFTTVAFARVVG
IRIKPEQANLQAWYDRIKERPSAQV