Protein Info for PGA1_c03440 in Phaeobacter inhibens DSM 17395

Annotation: disulfide interchange protein tlpA-like protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 195 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details PF00578: AhpC-TSA" amino acids 60 to 167 (108 residues), 62.4 bits, see alignment E=1e-20 PF08534: Redoxin" amino acids 64 to 185 (122 residues), 57.5 bits, see alignment E=3.4e-19 PF00085: Thioredoxin" amino acids 77 to 115 (39 residues), 29.3 bits, see alignment 1.9e-10 PF13905: Thioredoxin_8" amino acids 77 to 168 (92 residues), 53.6 bits, see alignment E=5.8e-18

Best Hits

Swiss-Prot: 36% identical to TLPA_BRADU: Thiol:disulfide interchange protein TlpA (tlpA) from Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)

KEGG orthology group: None (inferred from 71% identity to sit:TM1040_3733)

Predicted SEED Role

"Thiol:disulfide oxidoreductase TlpA" in subsystem Biogenesis of c-type cytochromes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EIV7 at UniProt or InterPro

Protein Sequence (195 amino acids)

>PGA1_c03440 disulfide interchange protein tlpA-like protein (Phaeobacter inhibens DSM 17395)
MVWNPGDNMRLLRQLSLYMALTLGANAALAADPAVLADMRQGDMKKLVLHSAPKPVSSAE
FQLADGAGAATLGDYKGKIVLLNFWATWCAPCRKEMPQLSELQEEFGGDEFEVLTLATGR
NSPAGIQKFFDDTGITNLPRHQDPRQAVAREMAVLGLPITVLLNREGEEIARLRGDAEWN
SDSAKTIIRALIASD