Protein Info for HP15_3216 in Marinobacter adhaerens HP15

Annotation: inorganic diphosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00719: Pyrophosphatase
  • amino acids 18 to 174 (157 residues), 203.2 bits, E=9.8e-65

Best Hits

Swiss-Prot: 73% identical to IPYR1_PSESM: Inorganic pyrophosphatase 1 (ppa1) from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 93% identity to maq:Maqu_3439)

MetaCyc: 69% identical to inorganic pyrophosphatase (Escherichia coli K-12 substr. MG1655)
Triphosphatase. [EC: 3.6.1.25]; Inorganic diphosphatase. [EC: 3.6.1.25, 3.6.1.1]

Predicted SEED Role

"Inorganic pyrophosphatase (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

• glyphosate degradation III (2/7 steps found)
• (aminomethyl)phosphonate degradation (2/8 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.1 or 3.6.1.25

Sequence Analysis Tools

See E4PQB5 at UniProt or InterPro

Protein Sequence (175 amino acids)

>HP15_3216 inorganic diphosphatase (Marinobacter adhaerens HP15)
MQFDNIPAGKNPPEDIYVAIEIPANSSPVKYELDKDMGALLVDRFMATPMFYPANYGFIP
HTLADDGDPLDVLVVTPYPIQAGSVIRCRPVGVLNMEDEAGGDAKLVAVPHDKLTTTYHD
VKEIDDLPELLRDQIKHFFENYKTLEPGKWVKVQGWDNADAAKKAIVDSVNAYKG