Protein Info for HP15_3112 in Marinobacter adhaerens HP15

Annotation: beta-lactamase domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 321 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00753: Lactamase_B" amino acids 82 to 246 (165 residues), 62.8 bits, see alignment E=2.3e-21

Best Hits

KEGG orthology group: None (inferred from 57% identity to lch:Lcho_3845)

MetaCyc: 58% identical to methyl parathion hydrolase (Pseudomonas sp. WBC-3)
Aryldialkylphosphatase. [EC: 3.1.8.1]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.8.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PPK5 at UniProt or InterPro

Protein Sequence (321 amino acids)

>HP15_3112 beta-lactamase domain protein (Marinobacter adhaerens HP15)
MLTRITGLTAGVLFAAAAQAEAPMVKEQAPGYYRTMLGNFEITALSDGTVKLPVDKLLLN
TTEEHVHNTLADNFLSAPLDTSVNGYLINTGNHLVLVDTGAGSLFGPTLGKLVEHLKASG
YEPADVDEIYITHMHPDHVGGLVSDGEIVFPNAIVRASVEDQNFWLNEDNLKAADEGSKG
FFKGAMASLNPYVESGQFKPFDKDQELVPGISAVSASGHTPGHSLYKVESGDNTLMLWGD
LIHVAAVQFPQPDIAIQFDVNSEQAVESRAQAFADAQETGYWVGSAHLSFPGLGHLKSAD
QGYEFIPANYQGGVGATETGE