Protein Info for PGA1_c00300 in Phaeobacter inhibens DSM 17395

Annotation: guanidinobutyrase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: None (inferred from 86% identity to sil:SPOA0234)

Predicted SEED Role

"Agmatinase (EC 3.5.3.11)" in subsystem Arginine and Ornithine Degradation or Polyamine Metabolism (EC 3.5.3.11)

MetaCyc Pathways

superpathway of arginine and polyamine biosynthesis (17/17 steps found)
superpathway of polyamine biosynthesis I (8/8 steps found)
superpathway of putrescine biosynthesis (4/4 steps found)
L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
putrescine biosynthesis I (2/2 steps found)
superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.3.11

Use Curated BLAST to search for 3.5.3.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7EI47 at UniProt or InterPro

Protein Sequence (326 amino acids)

>PGA1_c00300 guanidinobutyrase (Phaeobacter inhibens DSM 17395)
MSDPHLNAMMENLYWWGIPTLFRCPNLPVDGQDIALVGVPHSAGNGTTERDQHLGPRALR
NVSSVQRRMHSGFQLDPWNAAKIVDLGDVPFPKANDNEDCIQQITNFYQQIDKAGARPVS
VGGDHSITGGIVQALGCGAITKGEPICFLHLDAHTDVFTKVDHFLGAKKSAAHWGAYLAD
QGKVDPAHSMQIGIRGHARTLDWLQPSYEYGYNVVTMKDYRRRGLADVVAQVTEVLAGRP
VYITFDLDCLDPTIAPGVSNIEAGEKGFGIDDAVGLLHAVRGMNIVGGDVVCMMPTKDSP
NQITALTAGAIMFEIISMIAENHLSQ