Protein Info for PGA1_c29430 in Phaeobacter inhibens DSM 17395

Annotation: 3-mercaptopyruvate sulfurtransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00581: Rhodanese
  • amino acids 9 to 129 (121 residues), 58.9 bits, E=2.9e-20
  • amino acids 163 to 271 (109 residues), 43.9 bits, E=1.4e-15

Best Hits

KEGG orthology group: K01011, thiosulfate/3-mercaptopyruvate sulfurtransferase [EC: 2.8.1.1 2.8.1.2] (inferred from 84% identity to sit:TM1040_2634)

Predicted SEED Role

"Thiosulfate sulfurtransferase, rhodanese (EC 2.8.1.1)" (EC 2.8.1.1)

MetaCyc Pathways

• thiosulfate disproportionation IV (rhodanese) (1/1 steps found)
• L-cysteine degradation III (1/2 steps found)
• sulfide oxidation IV (mitochondria) (2/5 steps found)

KEGG Metabolic Maps

• Cysteine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.8.1.1 or 2.8.1.2

Sequence Analysis Tools

See I7E486 at UniProt or InterPro

Protein Sequence (283 amino acids)

>PGA1_c29430 3-mercaptopyruvate sulfurtransferase (Phaeobacter inhibens DSM 17395)
MDDPKTLVSTDWLAAHLKDPDLRLLDASWYMPQEGRDPKAEYAAAHIPGARFFDIDDIAD
NRSDLPHMVPPVEKFMSRLRAMGVGDGHQVVVYDGTGLRSAARVWWLFRLMGQTNIAVLD
GGLPKWQAEGNPVEDLPPVIRDRHMTVRVQNHLLRDVTQVSSAAKLGDHEIIDARAAERF
QGAVAEPREGLRAGHIPGSRNVPYTELLNADQTMKSPDALRAVFEKAGVDLSKPAITTCG
SGVTAAVLSLAMERFGKTDHALYDGSWTEWGAFPTLPVATGEA