Protein Info for HP15_2756 in Marinobacter adhaerens HP15

Annotation: metallo-beta-lactamase superfamily protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 676 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00753: Lactamase_B" amino acids 137 to 240 (104 residues), 57.4 bits, see alignment E=4.9e-19 PF12706: Lactamase_B_2" amino acids 149 to 223 (75 residues), 29.9 bits, see alignment E=1e-10 PF14863: Alkyl_sulf_dimr" amino acids 396 to 544 (149 residues), 188.7 bits, see alignment E=1.6e-59 PF14864: Alkyl_sulf_C" amino acids 554 to 676 (123 residues), 110.5 bits, see alignment E=1.7e-35 PF02036: SCP2" amino acids 578 to 653 (76 residues), 23.2 bits, see alignment E=1.8e-08

Best Hits

KEGG orthology group: None (inferred from 52% identity to psa:PST_0218)

Predicted SEED Role

"Alkyl sulfatase (EC 3.1.6.-)" (EC 3.1.6.-)

Isozymes

Compare fitness of predicted isozymes for: 3.1.6.-

Use Curated BLAST to search for 3.1.6.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PLC9 at UniProt or InterPro

Protein Sequence (676 amino acids)

>HP15_2756 metallo-beta-lactamase superfamily protein (Marinobacter adhaerens HP15)
MPLSRKLLFAPLLGIALVMTGCDSSPDSSAANSAGHIAPTATTEQANRDVLDQRPFDNRD
DFENARRGLIAQDPELVIDHLEGGEVWNMPAYGFIDEDGESAPASVNPSLWRQAALNNIH
GLFKVTDGLYQIRGYDLANMSIIEGETGWILVDPLTARETASKAFLFAREHLGEKPVRAI
LFTHSHIDHFGGVQGILQHLSDEEKANLRIIAPEGFEEEATSENIIAGPAMTRRAMFMYG
KRLDRDERGHVGTGLGKGPAFGTFGFAPATDLISETGTELEVDGVPMIFQIVSGSEAPAE
FTFYLPEQKAFCGAELVSRNMHNIYTLRGAKVRDARLWSSFIDEAKTLFADADIYFGSHH
WPLWGQENIQDFLAVQRDTYKFIHDQTVRLMNQGATPREIADQLKLPPELNQAFHNQGYY
GTVSHNAKAVYQHYLGWFTANPAQLDPLPESDSAQRYVQMMGGAEKVLERAREDFEAASA
MGASEGRDTYRWLAELLNQVVFAEPGNDDAKQLLANVYDQLGYQAESAPWRDFYLTGAYE
LRHGSPEEGIKPAMMREVLLNTPVSLFFDSMAVRLKAEDAEGESAVIKITFTDLKESYLL
TLKHSVLHNRLVNEDTPADATLNLTRSLFVDLLIGRAGLKELLFSDEISFEGSRLDLIGF
FSMLDKPQGRFNIVTP