Protein Info for PGA1_c28480 in Phaeobacter inhibens DSM 17395

Annotation: hybrid histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1044 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 486 to 504 (19 residues), see Phobius details PF00497: SBP_bac_3" amino acids 31 to 247 (217 residues), 86.5 bits, see alignment E=4.1e-28 amino acids 257 to 474 (218 residues), 105.9 bits, see alignment E=4.5e-34 PF00512: HisKA" amino acids 665 to 729 (65 residues), 28 bits, see alignment 3.7e-10 PF02518: HATPase_c" amino acids 771 to 905 (135 residues), 60 bits, see alignment E=6e-20 PF00072: Response_reg" amino acids 929 to 1038 (110 residues), 57.9 bits, see alignment E=2.2e-19

Best Hits

Predicted SEED Role

"Chemotaxis regulator - transmits chemoreceptor signals to flagelllar motor components CheY" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7E400 at UniProt or InterPro

Protein Sequence (1044 amino acids)

>PGA1_c28480 hybrid histidine kinase/response regulator (Phaeobacter inhibens DSM 17395)
MARPIRFLFSFLVLVTMALPGWSQDGPNPLRIGFLSVPPFAQRDSQGQETGFLVELAQDL
ATELGTSITLVPVTSSRDFVQAQAEGRTDLIAGIAQLPALRNSNLFSTPISSETLRPMMR
TDTVQGHSTATLSGVRVGIVPPAVGSEQEAFLARNTTVNFTTPEAAVMALLSHRVDAVLV
PEPVAFNIAKLASVDGRVSFLNPPLRQFDRLVALHESRADLMPDIEAALDRMKQDRRLDA
LLLKYFLDIPLPAPDVLRVGVYPSPPYQVINADGQVSGFAVDVLRGLARRTGLQLEFQTI
SEEAWLRGPQSDTYDILPAAQITATRQAQMDFAHPILAAEQSLFTQVDLADRITRPEDLS
ARRVGVRADNATAQAMGAALDWQVVPMGSVPALLTALQTGQVDAVVDHPDKLLVAAENLR
MRDALTEVLPALLSYERAPALRFGLGDVRDKLDLALPQYLVSAEYAELRRKYFEPPVLWN
AARLRLLGYAIGGGLLTLLGVLGLNKLRTRRRIAADKARRAAEIAEIRDELEVVLNAATS
GIVAFDRAGQIIRINHPARHMLGDISAETPFAWPEAIRFLNKDTLSPLIASADPLQRARS
GHVLSGETHLLRRSANSDDHRYVRVRSAVPKNEHQGVALVLVLDDVTNEELNRQVNDRRN
RLDALGELTGGIAHDINNLLASLLYAVDLAGTATTSEHRARFLGIATTTINRGRQLTTRL
LAFAKRQPGFAMAKPVQETLTEFHDLIRPMLETRIEIQVQEADPDLLVYCDPAQLETALM
NLVLNSRDAIMSSGHGTRIILKARPVAAPQDRPGAKSRNDDKGLGTSAANANHRYVELSV
TDDGPGMNNATLIRCTDPFFTTKDANSGTGLGLSMVYGFARHSNGDLRVYSQPGGGTTVQ
LTLPRGSDLSLPKTAAPDTPLEKGAGETILLAEDEPDLREMTRDMLVTLGYQVLSVGSAQ
QALELLQDSNPFDLLLTDVVMPGSIGGFELANRIRQVHPGMPVIYTSGFTGYTPDEMGPV
TAPLLQKPVHPRDLAAALAAVLRQ