Protein Info for Psest_2832 in Pseudomonas stutzeri RCH2

Annotation: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01853: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD
  • amino acids 11 to 331 (321 residues), 376.8 bits, E=3.9e-117
• PF04613: LpxD
  • amino acids 26 to 91 (66 residues), 80.9 bits, E=4.9e-27
• PF00132: Hexapep
  • amino acids 118 to 151 (34 residues), 27.8 bits, 1.5e-10

Best Hits

Swiss-Prot: 80% identical to LPXD_PSEMY: UDP-3-O-acylglucosamine N-acyltransferase (lpxD) from Pseudomonas mendocina (strain ymp)

KEGG orthology group: K02536, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC: 2.3.1.-] (inferred from 90% identity to psa:PST_1547)

MetaCyc: 49% identical to UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase (Escherichia coli K-12 substr. MG1655)
UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN [EC: 2.3.1.191]

Predicted SEED Role

"UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.191)" (EC 2.3.1.191)

MetaCyc Pathways

• lipid IV_A biosynthesis (P. gingivalis) (9/9 steps found)
• superpathway of (Kdo)₂-lipid A biosynthesis (14/17 steps found)
• lipid IV_A biosynthesis (E. coli) (6/6 steps found)
• lipid IV_A biosynthesis (H. pylori) (6/6 steps found)
• lipid IV_A biosynthesis (P. putida) (6/6 steps found)
• lipid IV_A biosynthesis (Vibrio cholerae serogroup O1 El Tor) (6/6 steps found)
• lipid IV_A biosynthesis (generic) (6/6 steps found)
• lipid IV_A biosynthesis (2,3-diamino-2,3-dideoxy-D-glucopyranose-containing) (5/6 steps found)
• superpathway of Kdo₂-lipid A biosynthesis (17/25 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• Alkaloid biosynthesis I
• Alkaloid biosynthesis II
• Anthocyanin biosynthesis
• Benzoate degradation via CoA ligation
• Biosynthesis of terpenoids and steroids
• Biosynthesis of type II polyketide backbone
• Biosynthesis of unsaturated fatty acids
• Butanoate metabolism
• Carotenoid biosynthesis - General
• Diterpenoid biosynthesis
• Ether lipid metabolism
• Ethylbenzene degradation
• Fatty acid biosynthesis
• Glycerophospholipid metabolism
• Glycosphingolipid biosynthesis - ganglio series
• Histidine metabolism
• Limonene and pinene degradation
• Lipopolysaccharide biosynthesis
• Lysine degradation
• Phenylalanine metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.-

Use Curated BLAST to search for 2.3.1.- or 2.3.1.191

Sequence Analysis Tools

See L0GNF5 at UniProt or InterPro

Protein Sequence (352 amino acids)

>Psest_2832 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (Pseudomonas stutzeri RCH2)
MAGAVFTLGQLAGELGGSLRGDAALIVSGLATLQEAGPSQLSFLANAQYRKYLAVTQAAA
VLLSPADAEAYDRPAIIVSDPYLAYARASHLFETRPQTASGIHPTALVAADAHVHPSASI
GPYVVIESGASIEADVVIGAQSFIGARSRIGEGGRLAPRVTLYHDVLIGKRVVIQSGAVI
GGEGFGFAKEKGAWQKIAQIGGVRIGDDVEIGSNTTIDRGALSDTLIGNGVKLDNQIMIA
HNVQVGDNTAMAGCAGISGSTKIGRNCMIAGGVGMVGHIEVCDNVFVTGMTMVTRSITEP
GSYSSGTAMQNAADWRKSAARIRQLDDMARRLQQLEKSLAAVTQAQNPASDA