Protein Info for HP15_2715 in Marinobacter adhaerens HP15

Annotation: low specificity L-threonine aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01212: Beta_elim_lyase
  • amino acids 6 to 296 (291 residues), 222.1 bits, E=4.8e-70

Best Hits

Swiss-Prot: 63% identical to LTAE_PSEUN: Low specificity L-threonine aldolase (ltaE) from Pseudomonas sp. (strain NCIMB 10558)

KEGG orthology group: K01620, threonine aldolase [EC: 4.1.2.5] (inferred from 67% identity to rpf:Rpic12D_0824)

Predicted SEED Role

"Low-specificity L-threonine aldolase (EC 4.1.2.48)" (EC 4.1.2.48)

MetaCyc Pathways

• L-threonine degradation IV (2/2 steps found)
• glycine biosynthesis IV (1/1 steps found)
• superpathway of L-threonine metabolism (12/18 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.2.48

Use Curated BLAST to search for 4.1.2.48 or 4.1.2.5

Sequence Analysis Tools

See E4PKK3 at UniProt or InterPro

Protein Sequence (343 amino acids)

>HP15_2715 low specificity L-threonine aldolase (Marinobacter adhaerens HP15)
MSQSEQFASDNYSGVCPQAWKAMEAANRMDEPAYGEDSWTQKAADGLRTLFDTDCDVYFV
FNGTAANSLALASIGQSFHSVICHELAHIETDECGGPEYASNGAKLLLGQGENGKLTPES
IEHLVTKRTDIHYPKPKALSLTQATEVGTVYTPEELKVIRSVADRHKLNIHMDGARFANA
VAALDVHPAEITWKAGVDVLCFSGTKNGLALGEAVVFFNRSLAEDFEWRCKQAGQLASKM
RYISAPWCGLLEGDVWLQNARHANACAQRLAAGLEGLPGIQLRYPRQVNGVFVEMPEPLQ
AALRAKGWRFYNFIGGSARLMCSWATTNEQVDRFLSDVRALVS