Protein Info for HP15_272 in Marinobacter adhaerens HP15

Annotation: biosynthetic arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 8 to 635 (628 residues), 833.6 bits, E=5.1e-255
• PF02784: Orn_Arg_deC_N
  • amino acids 89 to 346 (258 residues), 147.8 bits, E=5.7e-47
• PF17810: Arg_decarb_HB
  • amino acids 372 to 457 (86 residues), 90.8 bits, E=8.3e-30
• PF17944: Arg_decarbox_C
  • amino acids 585 to 634 (50 residues), 61.6 bits, 1.2e-20

Best Hits

Swiss-Prot: 84% identical to SPEA_MARHV: Biosynthetic arginine decarboxylase (speA) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 84% identity to maq:Maqu_0520)

MetaCyc: 54% identical to biosynthetic arginine decarboxylase (Escherichia coli K-12 substr. MG1655)
Arginine decarboxylase. [EC: 4.1.1.19]

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (14/17 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of polyamine biosynthesis II (6/8 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• superpathway of polyamine biosynthesis I (5/8 steps found)
• spermidine biosynthesis III (2/4 steps found)
• superpathway of putrescine biosynthesis (2/4 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Sequence Analysis Tools

See E4PKZ4 at UniProt or InterPro

Protein Sequence (636 amino acids)

>HP15_272 biosynthetic arginine decarboxylase (Marinobacter adhaerens HP15)
MSEASATPAHKVYNIAHWSDGYIGVNDQGQVLIRPDRGHSPARINLPELTRTLTESGVQL
PVLVRFVDILHDRVNKLCNAFNKVAEEHAYQGGYTAVYPIKVNQQRRVVEELLAAEPAAS
NGQIGLEAGSKPELMAVLAMSQQPGSVIVCNGYKDREYIRLALIGQTLGHRVFIVVEKKS
ELPLILEEAKSLGVSPLIGVRARLATIGKGNWQNTGGEKSKFGLSASQVLDVVDTLREAG
ALDTLQLLHFHLGSQIANIRDIQTGLRECARFYSELRQMGAPIGTVDIGGGLGVDYEGTR
SRSSCSMNYSVYEYAYNVVHVLQAECDRHGTPHPDLISESGRALTAHHSVLVTNVIDHEA
PENRTPQQPGATASAPLHDLWRDLESLQDTNTPRSLAEIYHDVLHAMADVHAQFAHGVLS
LQERADAETLYTRCCRLLRDQLDSSNRAHREIIDELNEKLAEKLFVNFSLFQSLPDVWGI
DQIFPVMPINGLDRPLNRRAVIQDITCDSDGRIDRYVDGQGTETTLPLPEERSGEPLLMG
FFMTGAYQEILGDMHNLFGDTHSVDVRLTPEGGYEISAPITGDTVAKVLRYVNFEPEALM
EAYRGKFAASALAAETQAALMAELAAGLDGYTYLEE