Protein Info for HP15_2597 in Marinobacter adhaerens HP15

Annotation: two component, sigma54 specific, transcriptional regulator, Fis family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 634 PF06506: PrpR_N" amino acids 37 to 194 (158 residues), 116.8 bits, see alignment E=1.6e-37 PF00158: Sigma54_activat" amino acids 310 to 475 (166 residues), 203.4 bits, see alignment E=4.1e-64 PF14532: Sigma54_activ_2" amino acids 328 to 481 (154 residues), 63.5 bits, see alignment E=5e-21 PF02954: HTH_8" amino acids 581 to 619 (39 residues), 49.8 bits, see alignment 4.6e-17

Best Hits

Predicted SEED Role

"Response regulator of zinc sigma-54-dependent two-component system" in subsystem Zinc resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PJJ7 at UniProt or InterPro

Protein Sequence (634 amino acids)

>HP15_2597 two component, sigma54 specific, transcriptional regulator, Fis family (Marinobacter adhaerens HP15)
MMEFNNAEADRVKLCLIGNSKLSKMVHSLIPEFQSIAEIVIIDSIFNDALMSARRLVEHD
AVDVFISAGANAHYLKDTLPVPVVALELRQSDLVNAVLKARQISNKILLLTYEHQSTWTE
FLDYVEGVDIVHRTYKTAEEARETFHGVEKDGIGVVIGSSFICDLAEQEGLPFVMVYSRE
SCRYMVRKAISVAGEHKREGERRAFVQFLMDSASSPTIITNRDEQIIGFNRSALGLVKGL
ARNKRIDRFLDSRFLQTPDTVAEGIQVGDRLCRVQKSAFEVDGVRVGHLYALTAAPQSKS
GSEGKTSGLIYESGRMAEVAHFLQVYGATPGAVLLRGETGTGKELAARMIHDSSANKEGP
FVAINCAAIPSELFESELFGYADGAFTSSRSGGKSGLLETANNGTFFMDEINSLPLPQQA
KLLRVLQEREVRPVGSRRSIALNIKFVAACNHDLLEEVRAGRFREDLYYRLNVFIVNLPP
LRERPDDIEPLTRHFIQSLGRQYGIDADENALAEVLVPRFRRYGWPGNVRQLENLMERLL
VSSTLYSSTEQFASHLQSLAPELFELTDLGQSGLTEGCHLQSVEQEEILKVLGRFGGNKT
KAAEYLGISQTTLWRRLKQMSADPRAVGNDQSGE