Protein Info for HP15_26 in Marinobacter adhaerens HP15

Annotation: drug resistance transporter, Bcr/CflA family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 398 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 49 to 68 (20 residues), see Phobius details amino acids 80 to 98 (19 residues), see Phobius details amino acids 104 to 125 (22 residues), see Phobius details amino acids 137 to 162 (26 residues), see Phobius details amino acids 167 to 186 (20 residues), see Phobius details amino acids 220 to 242 (23 residues), see Phobius details amino acids 254 to 274 (21 residues), see Phobius details amino acids 286 to 304 (19 residues), see Phobius details amino acids 311 to 334 (24 residues), see Phobius details amino acids 346 to 367 (22 residues), see Phobius details amino acids 373 to 392 (20 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 14 to 391 (378 residues), 330.9 bits, see alignment E=7.2e-103 PF07690: MFS_1" amino acids 17 to 361 (345 residues), 166.1 bits, see alignment E=1.1e-52 PF00083: Sugar_tr" amino acids 45 to 182 (138 residues), 41.7 bits, see alignment E=7.7e-15

Best Hits

Swiss-Prot: 32% identical to BCR_HAEIN: Bicyclomycin resistance protein homolog (bcr) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 48% identity to cti:RALTA_B1137)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PI85 at UniProt or InterPro

Protein Sequence (398 amino acids)

>HP15_26 drug resistance transporter, Bcr/CflA family protein (Marinobacter adhaerens HP15)
MKLQKLASFFPGWLFLLAMLTALSPLSVDLYLPAFPAIAESLNVNSAQIQVTLAAYLLGM
AVGQLLYGPLSDHFGRKPPLYFGLALYVLASFACVFASDLTTLTIARFVQALGGSSGVVI
SRAVIRDRTKPAQSAKAFSMLMLALGLAPILAPLLGGFLLYIMGWRGIFAVLGVTGIVLF
ISTHYSMRETHFREPNAHLSLWSVLTRYLELLREWQFQKYVLVAGMLFGGMFAYVAGSPF
IVIELFEVPPEHFGWFFGINAIGMIAGSQINANLATRYGPEKVLKHVIWIPFVASLLGFS
SAVLQFDSLPLLMLCFFAFMTSMGLLSPNAMALAMASQGHRAGSASAIMGAIQFLIGTLG
ATVISFWPLPSAVPLMTVMLISTAGSLFFFLLGKKTRA