Protein Info for PGA1_c25110 in Phaeobacter inhibens DSM 17395

Annotation: ATP synthase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 512 TIGR00962: ATP synthase F1, alpha subunit" amino acids 3 to 511 (509 residues), 801.7 bits, see alignment E=1.3e-245 PF02874: ATP-synt_ab_N" amino acids 25 to 92 (68 residues), 73.2 bits, see alignment E=3e-24 PF00006: ATP-synt_ab" amino acids 149 to 374 (226 residues), 274.9 bits, see alignment E=7.2e-86 PF00306: ATP-synt_ab_C" amino acids 381 to 507 (127 residues), 146.5 bits, see alignment E=8.1e-47

Best Hits

Swiss-Prot: 92% identical to ATPA_RUEST: ATP synthase subunit alpha (atpA) from Ruegeria sp. (strain TM1040)

KEGG orthology group: K02111, F-type H+-transporting ATPase subunit alpha [EC: 3.6.3.14] (inferred from 92% identity to sil:SPO3164)

MetaCyc: 70% identical to ATP synthase subunit alpha, mitochondrial (Homo sapiens)

Predicted SEED Role

"ATP synthase alpha chain (EC 3.6.3.14)" in subsystem F0F1-type ATP synthase (EC 3.6.3.14)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.14

Use Curated BLAST to search for 3.6.3.14

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F1J9 at UniProt or InterPro

Protein Sequence (512 amino acids)

>PGA1_c25110 ATP synthase subunit alpha (Phaeobacter inhibens DSM 17395)
MGIQAAEISAILKDQIKNFGQEAEVAEIGRVLSVGDGIARVYGLDNVQAGEMVEFPGGIM
GMALNLEADNVGIVIFGSDRDIKEGDTVKRTNSIVDVPAGPELLGRVVDGLGNPLDGKGP
INAKERKVADVKAPGIIPRKSVHEPMATGLKSVDAMIPIGRGQRELIIGDRQTGKTAVAL
DAILNQKVYNDAAGDDESKKLYCVYVAIGQKRSTVAQLVKKLEETGAMEYSIVVAATASE
PAPMQFLAPYAATAMAEYFRDSGKHALIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDV
FYLHSRLLERSAKLNEEFGAGSLTALPVIETQGGDVSAFIPTNVISITDGQIFLETELFY
QGIRPAVNTGLSVSRVGSSAQTNAMKSVAGPVKLELAQYREMAAFAQFGSDLDAATQQLL
NRGARLTELMKQPQYAPLTNAEIVCVIFAGTNGYLDKVGVKAVGRYEAGLLAHLRSKHQD
LLDWITTEDPKIKGDAADKIKAALDAFAADFA