Protein Info for PGA1_c25010 in Phaeobacter inhibens DSM 17395

Annotation: low specificity L-threonine aldolase LtaE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01212: Beta_elim_lyase
  • amino acids 3 to 290 (288 residues), 174.1 bits, E=2.1e-55

Best Hits

KEGG orthology group: K01620, threonine aldolase [EC: 4.1.2.5] (inferred from 73% identity to sil:SPO3156)

Predicted SEED Role

"Low-specificity L-threonine aldolase (EC 4.1.2.48)" (EC 4.1.2.48)

MetaCyc Pathways

• superpathway of L-threonine metabolism (15/18 steps found)
• L-threonine degradation IV (2/2 steps found)
• glycine biosynthesis IV (1/1 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.48 or 4.1.2.5

Sequence Analysis Tools

See I7F1I9 at UniProt or InterPro

Protein Sequence (344 amino acids)

>PGA1_c25010 low specificity L-threonine aldolase LtaE (Phaeobacter inhibens DSM 17395)
MHFASDNSGPANPEILTALSAANTGYAMGYGADEEMAKVTSCIREIFEAPQAAVYLVATG
TAANVLALSTLSQPWQTLFCTRQAHINVDECNGPEFYTGGAKLTLVSDADKMTPADLRQA
LEGEENRGVHGPQRGPVSITQVTEFGTVYTLDELRALCDVSKSYGLPVHLDGARFTNALV
SLGCTPAEMTWKAGVDVVSFGGTKNGCMGVEAVIFFDPAEAQEFEYRRKRGAHLFSKHRY
LSAQMLAYLTDDLWLRNASAANAKAARLAAGLRNAGAHFSHDPQANMIFAALPRATHQRL
FDAGAVYHLWDGTLDGAAEEAVTARFVCDWSVGDDQIDAFLALL