Protein Info for HP15_2406 in Marinobacter adhaerens HP15

Annotation: metallo-beta-lactamase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 453 PF00753: Lactamase_B" amino acids 17 to 196 (180 residues), 58.4 bits, see alignment E=2.5e-19 PF16661: Lactamase_B_6" amino acids 18 to 190 (173 residues), 43.6 bits, see alignment E=5.8e-15 PF12706: Lactamase_B_2" amino acids 24 to 221 (198 residues), 49.8 bits, see alignment E=8.7e-17 PF10996: Beta-Casp" amino acids 249 to 368 (120 residues), 128.4 bits, see alignment E=5.5e-41 PF07521: RMMBL" amino acids 383 to 445 (63 residues), 57.6 bits, see alignment E=2.6e-19

Best Hits

KEGG orthology group: K07576, metallo-beta-lactamase family protein (inferred from 89% identity to maq:Maqu_2652)

Predicted SEED Role

"Metallo-beta-lactamase family protein, RNA-specific" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PH67 at UniProt or InterPro

Protein Sequence (453 amino acids)

>HP15_2406 metallo-beta-lactamase family protein (Marinobacter adhaerens HP15)
MKLRFLGGTGTVTGSRYLLSDEKHRVLVDCGMYQGVKTLRRRNWAKFPVDPSTIDAVVLT
HAHIDHSGYLPALVKNGFKGKVYCTKATHELCKVLLPDAGFLQEEDAKYAFRKKFSKHEK
PEPLFTEKDAWEALKHFESLHYHEAFEPVKGFQVTFTPAGHILGSSCVHVHHQGADRTVV
FSGDVGRQNDIIMRPPEPLQKADVLICESTYGDRAHGETDPEAELAEIITRTAGRGGIVL
LPAFAVGRAQMLLYVIHKIMGDGKIPKLPVFLNSPMAIKATEIFCKHHKEHKLNAAQCEL
MDEKTEFVRTVEESIELDAVRYPCVIISASGMASGGRVLHHLKTLLPNPRNSVVFAGFQA
PGTRGDALVNGAESVKIHGEYWPVKAEIHNLDSLSAHGDYNEILAWLGQSSLKPEKVYVT
HGELVASDVMRKRIRDKFGWDVEVPELFEEVEV