Protein Info for HP15_2330 in Marinobacter adhaerens HP15

Annotation: two component, sigma54 specific, transcriptional regulator, Fis family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 477 PF06490: FleQ" amino acids 2 to 115 (114 residues), 78.3 bits, see alignment E=1.6e-25 PF00158: Sigma54_activat" amino acids 139 to 306 (168 residues), 253.7 bits, see alignment E=2.2e-79 PF14532: Sigma54_activ_2" amino acids 140 to 310 (171 residues), 71.5 bits, see alignment E=2.8e-23 PF07728: AAA_5" amino acids 163 to 281 (119 residues), 30.6 bits, see alignment E=9.5e-11 PF25601: AAA_lid_14" amino acids 311 to 387 (77 residues), 75.5 bits, see alignment E=7.1e-25 PF02954: HTH_8" amino acids 427 to 467 (41 residues), 45.5 bits, see alignment 1.6e-15

Best Hits

KEGG orthology group: K10941, sigma-54 specific transcriptional regulator, flagellar regulatory protein A (inferred from 89% identity to maq:Maqu_2001)

Predicted SEED Role

"Flagellar regulatory protein FleQ" in subsystem Flagellum

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PGI3 at UniProt or InterPro

Protein Sequence (477 amino acids)

>HP15_2330 two component, sigma54 specific, transcriptional regulator, Fis family (Marinobacter adhaerens HP15)
MLVLSEDDSRLRDIVTILEFIGEEQVLAGDEARALLSSGDEESLSDIAVAVVNGEDAGAT
EAITAVCDAVQGVPFLVVGHPELKGLSDEISGRIIARMEWPLNYTKFVDSLYRAQIYRDQ
FTRSRERGQQRGLQLFRSLVGTSRKVQQVRQLMEQVADKDVSVLITGESGTGKEVVARNL
HYHSSRRDKPFVPVNCGAIPAELLESELFGHEKGAFTGAITARVGRFEMAEGGTLFLDEI
GDMPLNMQVKILRVLQERTFERVGSNRTQSADVRVIAATHKHLEDMIESGDFREDLYYRL
NVFPIEMPALRDRVEDIPLLINELISRMEKEKRGSLRMNSAAIMSLCRHDWPGNVRELAN
LVERLSIMHPYGVIGVQELPKKFRYVDDYDENRPVEDTGMPSGIPGLVGLDAPALLPVNG
IDLKDYLSNLEKQLIQQALDEAGGVVARAAEKLRIRRTTLVEKVRKYGLREEESEES