Protein Info for HP15_2268 in Marinobacter adhaerens HP15

Annotation: carbonate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00484: Pro_CA
  • amino acids 37 to 188 (152 residues), 179.6 bits, E=2.6e-57

Best Hits

Swiss-Prot: 49% identical to CAN_ECOLI: Carbonic anhydrase 2 (can) from Escherichia coli (strain K12)

KEGG orthology group: K01673, carbonic anhydrase [EC: 4.2.1.1] (inferred from 89% identity to maq:Maqu_1943)

MetaCyc: 49% identical to carbonic anhydrase 2 (Escherichia coli K-12 substr. MG1655)
Carbonate dehydratase. [EC: 4.2.1.1]

Predicted SEED Role

"Carbonic anhydrase (EC 4.2.1.1)" in subsystem Carboxysome or Cyanate hydrolysis (EC 4.2.1.1)

MetaCyc Pathways

• cyanate degradation (3/3 steps found)
• CO₂ fixation into oxaloacetate (anaplerotic) (2/2 steps found)
• C4 photosynthetic carbon assimilation cycle, NADP-ME type (4/7 steps found)
• C4 photosynthetic carbon assimilation cycle, PEPCK type (9/14 steps found)
• C4 photosynthetic carbon assimilation cycle, NAD-ME type (6/11 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (10/18 steps found)
• 3-hydroxypropanoate cycle (5/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (8/18 steps found)
• glyoxylate assimilation (4/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (5/18 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (20/56 steps found)

KEGG Metabolic Maps

• Nitrogen metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.1

Sequence Analysis Tools

See E4PFW2 at UniProt or InterPro

Protein Sequence (227 amino acids)

>HP15_2268 carbonate dehydratase (Marinobacter adhaerens HP15)
MGQLDHLLEKNRAWADGIKAQDPQFFTRLSNQQAPEYLWIGCADSRVPANQIVDLLPGEL
FVHRNVANVVVHTDFNCLSVLQFAIEVLKVKHVLVVGHYGCGGVRAALLNEGFGLISNWL
RHVQDVRDRHQQVLDALPGVQDRVDRLCELNVVEQVGHVCQNSIVQEAWRRGQPLTVHGF
VYDVSDGVLRDMGLSVACEEDRERVRQNSIDELVQRPVRSGRQKIVQ