Protein Info for PGA1_c23170 in Phaeobacter inhibens DSM 17395

Annotation: succinate-semialdehyde dehdyrogenase GabD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 14 to 469 (456 residues), 540.4 bits, E=1.6e-166

Best Hits

Swiss-Prot: 54% identical to SSDH_PAENI: Succinate-semialdehyde dehydrogenase (sad) from Paenarthrobacter nicotinovorans

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 74% identity to pgv:SL003B_1037)

MetaCyc: 44% identical to Succinate-semialdehyde dehydrogenase, mitochondrial (Homo sapiens)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• 4-aminobutanoate degradation I (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (3/4 steps found)
• methylglyoxal degradation V (2/3 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• lactate biosynthesis (archaea) (3/5 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of methylglyoxal degradation (3/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• L-rhamnose degradation II (2/8 steps found)
• superpathway of fucose and rhamnose degradation (4/12 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22, 1.2.1.24

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22 or 1.2.1.24

Sequence Analysis Tools

See I7DSF6 at UniProt or InterPro

Protein Sequence (474 amino acids)

>PGA1_c23170 succinate-semialdehyde dehdyrogenase GabD (Phaeobacter inhibens DSM 17395)
MEYTDLYINGAWHKTSERFDVINPATEEVLASVASADIADADAALDAAEAAMKDWAARTP
RQRSEVLRKAWELMTKRLDYFANLITLENGKAGTDAKGEATYAAEFFRWFAEEAVRADGM
ITHAPASGARIVVQHKPAGLAVLVTPWNYPAAMGTRKIAPALAAGCGVIIKPASETPLTM
LALMPLLEEAGVPAGLVNVLPSRKTGSLVDHMLHDPRIRVVSFTGSTGVGRKLLKGAADQ
VLKPAMELGGNAPVVVFEDADMDVAIEGTMLAKMRNLGEACTAANRIYVHEDIADEFTKR
LSAAMSALKVGDGTDPSVDVGPLVNADTRDKVAAFVADAVAKGAKVECGGTTPNGKGFYY
PPTVLSNVSEDAECVRDEIFGPVAAIQTFTNQDEVIARANDTEYGLVAYVFSEDFKRALQ
VCEQLEYGMVGLNRGLVSDPAAPFGGVKQSGLGREGGHEGMLEFMETQYISASW