Protein Info for HP15_2177 in Marinobacter adhaerens HP15

Annotation: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01081: Aldolase
  • amino acids 17 to 210 (194 residues), 253.8 bits, E=4.6e-80
• TIGR01182: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
  • amino acids 18 to 215 (198 residues), 254.1 bits, E=3.6e-80

Best Hits

Swiss-Prot: 51% identical to ALKD_PSEPU: 2-dehydro-3-deoxy-phosphogluconate aldolase (eda) from Pseudomonas putida

KEGG orthology group: K01625, 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC: 4.1.2.14 4.1.3.16] (inferred from 82% identity to maq:Maqu_1832)

MetaCyc: 52% identical to 2-dehydro-3-deoxy-phosphogluconate aldolase (Pseudoalteromonas atlantica T6c)
2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14, 4.1.2.55]

Predicted SEED Role

"4-Hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)" (EC 4.1.2.14, EC 4.1.3.16)

MetaCyc Pathways

• superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
• Entner-Doudoroff pathway I (8/9 steps found)
• Entner-Doudoroff shunt (2/2 steps found)
• trans-4-hydroxy-L-proline degradation I (3/5 steps found)
• D-glucosaminate degradation (1/3 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (5/9 steps found)
• D-fructuronate degradation (1/4 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (1/5 steps found)
• D-galacturonate degradation I (1/5 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (2/7 steps found)
• superpathway of β-D-glucuronosides degradation (2/7 steps found)
• superpathway of hexuronide and hexuronate degradation (2/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (5/31 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glyoxylate and dicarboxylate metabolism
• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.14 or 4.1.2.55 or 4.1.3.16

Sequence Analysis Tools

See E4PF61 at UniProt or InterPro

Protein Sequence (221 amino acids)

>HP15_2177 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (Marinobacter adhaerens HP15)
MEKTVSQLSDYHRERVRAVLQSSPLVPVIAIQDLDDAVPLCQALVDGGINVLEITLRTEH
GLKAIEEVRKAIPDAWVGAGTVTSIAQYRQVEAAGAQFVITPGVTEAILEFGLTSEAPLL
PGIATISEMMIGYNLGYREFKFFPAEVAGGIPALKAFSGPFPDVTFCPTGGIRRNTAADY
LALGNVQAVGGTWLTPADLVAAKDWAQITEIARGSLADLAL