Protein Info for HP15_2097 in Marinobacter adhaerens HP15

Annotation: protease HtpX-like protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 293 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 35 to 58 (24 residues), see Phobius details amino acids 155 to 176 (22 residues), see Phobius details amino acids 192 to 216 (25 residues), see Phobius details PF01435: Peptidase_M48" amino acids 80 to 291 (212 residues), 134.8 bits, see alignment E=1.6e-43

Best Hits

Swiss-Prot: 70% identical to HTPX_PSEMY: Protease HtpX (htpX) from Pseudomonas mendocina (strain ymp)

KEGG orthology group: K03799, heat shock protein HtpX [EC: 3.4.24.-] (inferred from 89% identity to maq:Maqu_1774)

Predicted SEED Role

"Probable protease htpX homolog (EC 3.4.24.-)" (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PRF2 at UniProt or InterPro

Protein Sequence (293 amino acids)

>HP15_2097 protease HtpX-like protein (Marinobacter adhaerens HP15)
MRILLFLATNLAVILVASFTLRLLGVDSYLAQNGIQYGSLLAFAAVFGFAGAIVSLLISK
RMAKWSTRARVIDAPRTPAERWLVDTVAELAKNAGIGMPEVAIFPASQSNAFATGWNKND
ALVAVSEGLLHRFNKDEIRAVLGHEIGHVANGDMVTLALIQGVVNTFVIFASRVIGSFVD
RVIFKNESGHGLGFFAVSIVAEIVLGILASTIVFWFSRRREFRADIAGAQLAGRTAMISA
LARLKQESEVPDQMPDSLQAFGINRGARGGLSALFMTHPPLEDRIQALQHAKL