Protein Info for HP15_2061 in Marinobacter adhaerens HP15

Annotation: 3-deoxy-D-manno-octulosonate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 264 TIGR00466: 3-deoxy-D-manno-octulosonate cytidylyltransferase" amino acids 1 to 249 (249 residues), 316.8 bits, see alignment E=4.2e-99 PF02348: CTP_transf_3" amino acids 5 to 230 (226 residues), 215.2 bits, see alignment E=1e-67 PF12804: NTP_transf_3" amino acids 18 to 125 (108 residues), 50.4 bits, see alignment E=3e-17

Best Hits

Swiss-Prot: 80% identical to KDSB_MARHV: 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB) from Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)

KEGG orthology group: K00979, 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC: 2.7.7.38] (inferred from 80% identity to maq:Maqu_1738)

Predicted SEED Role

"3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38)" in subsystem KDO2-Lipid A biosynthesis (EC 2.7.7.38)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PRB6 at UniProt or InterPro

Protein Sequence (264 amino acids)

>HP15_2061 3-deoxy-D-manno-octulosonate cytidylyltransferase (Marinobacter adhaerens HP15)
MSFTVVIPARYASSRLPGKPLADIAGKPMIQHVCERAAESRADRVVVATDDDRIRTACEG
FGAEVVMTSPNHASGTDRLEEVARVLGFGPDHRVVNVQGDEPLIPPELINQVADNLEFYP
EVAIATLCERIHDPEHVFNPNVVKVVFDHRGIAHYFSRAPIPWARDQWQEGTPLTGLDAA
LPDNVGYFRHIGIYGYRASVLAEFVSWAPAPTELTESLEQLRALYNGARIHVDVAAVNPP
GGVDTDADLHRVRGWLEKRNSENG