Protein Info for PGA1_c21310 in Phaeobacter inhibens DSM 17395

Annotation: multidrug resistance protein NorM

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 464 transmembrane" amino acids 20 to 42 (23 residues), see Phobius details amino acids 62 to 87 (26 residues), see Phobius details amino acids 99 to 118 (20 residues), see Phobius details amino acids 138 to 155 (18 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 200 to 222 (23 residues), see Phobius details amino acids 244 to 271 (28 residues), see Phobius details amino acids 276 to 299 (24 residues), see Phobius details amino acids 323 to 342 (20 residues), see Phobius details amino acids 361 to 388 (28 residues), see Phobius details amino acids 398 to 419 (22 residues), see Phobius details amino acids 426 to 447 (22 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 26 to 429 (404 residues), 264.4 bits, see alignment E=8.1e-83 PF01554: MatE" amino acids 26 to 184 (159 residues), 109.6 bits, see alignment E=1.3e-35 amino acids 250 to 416 (167 residues), 98.3 bits, see alignment E=3.8e-32 PF14667: Polysacc_synt_C" amino acids 138 to 233 (96 residues), 39.9 bits, see alignment E=4.6e-14

Best Hits

Swiss-Prot: 45% identical to NORM_RHIME: Probable multidrug resistance protein NorM (norM) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 65% identity to sit:TM1040_1736)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7DRZ4 at UniProt or InterPro

Protein Sequence (464 amino acids)

>PGA1_c21310 multidrug resistance protein NorM (Phaeobacter inhibens DSM 17395)
MTQRIPPPAPNTLLGHSRAIAVLGLPLIGGHVAQFAIGLTDTVMLGWYGVEALAAVTLGS
TYFFTIFLLGSGFAFAVMPMVAAAAGAGEERQIRRSTRMALWLSLAYGLLVMPLLWWSEP
ILLLLGQEAEVAHGAAEYLRIAGWALFPALLYMVLKSYLAALERTQIVLLVSVLAAALNA
LINYALIFGNWGAPELGVTGAALASLATNVFACIFVLFYALKALPEHELLKNFQRPDWEM
LSRVLRLGLPIGLTNLSETSLFAASAMMMGWLGTVALGAHGIALSLGGLAFMMHLGLSNA
ATIRAGNAFGRGDRDHMARGARVVMAMSLGLSVLGMILFLAVPEALISLFLSPDDPDRAE
IVLIGSVLLAAAALFQLMDGMQVIALGLLRGVQDTGVPMVIAALSYWAVGIPASYLLGFT
FEMGGLGVWLGLVLGLTAAGVFLMIRFWRRSIKLVGTSKTAAAR