Protein Info for PGA1_c21300 in Phaeobacter inhibens DSM 17395

Annotation: arylsulfatase AtsA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 543 PF00884: Sulfatase" amino acids 13 to 424 (412 residues), 202 bits, see alignment E=2.1e-63 PF01663: Phosphodiest" amino acids 15 to 355 (341 residues), 37.4 bits, see alignment E=3.6e-13 PF16347: SGSH_C" amino acids 379 to 501 (123 residues), 41 bits, see alignment E=3.3e-14

Best Hits

KEGG orthology group: K01130, arylsulfatase [EC: 3.1.6.1] (inferred from 78% identity to sil:SPO3286)

Predicted SEED Role

"Choline-sulfatase (EC 3.1.6.6)" in subsystem Choline Transport or Choline and Betaine Uptake and Betaine Biosynthesis (EC 3.1.6.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.6.6

Use Curated BLAST to search for 3.1.6.1 or 3.1.6.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See I7F0N9 at UniProt or InterPro

Protein Sequence (543 amino acids)

>PGA1_c21300 arylsulfatase AtsA (Phaeobacter inhibens DSM 17395)
MTSNNPQAEISRPNVILILADDMGFADLGCTGSEIQTPNIDALARGGVMLSAMYNCARCC
PTRASLLTGLYPHNAGVGHMGANLGTPAYQGFLRNDSATIAEHLRASGYATLMSGKWHVA
GDFEAREVDSWRVGDVEHPTPRQRGFDRFYGIMDGATHFFSPHYMLEDDSRVETFPDDFY
FTDAITHKAIGMIEGAVADEKPFFLYLAHTAPHWPLHAHPEDIAKYDGVYDKGWDQIRTA
RHETMNGQGVFQRSWDISPRDRTVHGWEQEKNQDWEASKMATYAAMVDRMDQSIGTLIAA
LKRLGQFDNTLILFLSDNGGCAEFMAEDGWAKFYPDKTHDGRQITMGNVTGLRPGDAQTF
QSYDKPWANVSNAPFRLYKHYVHEGGISTPLVAHWPLGFKPRGNAHAACHVVDILPTILE
AAGAAYQTEVGGHDIQPLQGESLLGLFQGKDWQRAQPIFFEHEGNAAIRLGQFKLVRLHD
CPWELYDIEADRTELTDLAGRNPALEKDMFRQYQAWAQTAGVLDWNEALPKLLAAWKMET
PNG