Protein Info for HP15_2045 in Marinobacter adhaerens HP15

Annotation: DNA-binding transcriptional repressor FabR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 205 PF00440: TetR_N" amino acids 17 to 58 (42 residues), 36.3 bits, see alignment 4e-13 PF21943: TetR_C_46" amino acids 88 to 189 (102 residues), 43.5 bits, see alignment E=3.4e-15

Best Hits

Swiss-Prot: 63% identical to FABR_CITK8: HTH-type transcriptional repressor FabR (fabR) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: None (inferred from 93% identity to maq:Maqu_1708)

Predicted SEED Role

"Unsaturated fatty acid biosythesis repressor FabR, TetR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E4PQT9 at UniProt or InterPro

Protein Sequence (205 amino acids)

>HP15_2045 DNA-binding transcriptional repressor FabR (Marinobacter adhaerens HP15)
MATRAEQKQKTRRALMDAALSQLSADRGFGSLSLREVAREAGIAPTSFYRHFAELDELGL
ALVDEGGVALRQLMRQARKRIARDGGSAISTSVETFMEYLGNNANLFRLMLRERTGVSKP
FRTAVKAEIDHFVTELADDLRRIADEQNKPLSEARLVAEAMVTLVFNQGAEALDATASER
DELKAKLKTELRMILVGSQTLAKRN